2. Gene
  3. Cul3 - cullin 3 Gene

Cul3 - cullin 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: KIAA0617

基因 ID: 26554 | 基因类型: protein coding

关于 Cul3

功能概要

Enables cyclin binding activity and identical protein binding activity. Involved in embryonic cleavage; integrin-mediated signaling pathway; and stem cell division. Acts upstream of or within with a positive effect on protein polyubiquitination. Acts upstream of or within several processes, including embryonic morphogenesis; fibroblast apoptotic process; and liver morphogenesis. Located in Golgi apparatus and nucleus. Is expressed in several structures, including extraembryonic component; gonad; heart; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3). [provided by Alliance of Genome Resources, Apr 2022]

Cul3 基因产物(2)

mRNA Protein Name
NM_001313728.1 NP_001300657.1 cullin-3 isoform 2 precursor
NM_016716.5 NP_057925.1 cullin-3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cyclin binding IPI
IPI: 通过物理相互作用推断
10500095 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
22709582 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
22709582 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Wnt signaling pathway IDA
IDA: 通过直接分析推断
19056892 MGI
acts upstream of or within cell morphogenesis IMP
IMP: 通过突变表型推断
10500095 MGI
involved in embryonic cleavage IMP
IMP: 通过突变表型推断
22358839 MGI
acts upstream of or within fibroblast apoptotic process IMP
IMP: 通过突变表型推断
17339333 MGI
acts upstream of or within gastrulation IMP
IMP: 通过突变表型推断
10500095 MGI
involved in gene expression IMP
IMP: 通过突变表型推断
25250572 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
10500095 MGI
involved in inflammatory response IMP
IMP: 通过突变表型推断
25250572 MGI
involved in integrin-mediated signaling pathway IMP
IMP: 通过突变表型推断
22358839 MGI
acts upstream of or within liver morphogenesis IMP
IMP: 通过突变表型推断
17339333 MGI
acts upstream of or within mitotic cell cycle IMP
IMP: 通过突变表型推断
17339333 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17339333 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IGI
IGI: 通过遗传相互作用推断
20811152 MGI
involved in protein catabolic process IMP
IMP: 通过突变表型推断
25250572 MGI
acts upstream of or within positive effect protein polyubiquitination IDA
IDA: 通过直接分析推断
27708159 MGI
involved in protein ubiquitination IMP
IMP: 通过突变表型推断
25250572 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
24863065 MGI
involved in regulation protein catabolic process at postsynapse IDA
IDA: 通过直接分析推断
17062563 MGI
involved in regulation protein catabolic process at postsynapse IEP
IEP: 通过表达模式推断
17062563 MGI
involved in regulation protein catabolic process at postsynapse IMP
IMP: 通过突变表型推断
17062563 MGI
involved in stem cell division IMP
IMP: 通过突变表型推断
22358839 MGI
acts upstream of or within trophectodermal cellular morphogenesis IMP
IMP: 通过突变表型推断
10500095 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
10500095 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
24863065 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17062563 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
17062563 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
17062563 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10500095 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cullin-3

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126075A WS-383 Inhibitor 99.88% 否
HY-126075 WS-383 free base Inhibitor / 否
HY-124834 Nrf2 activator-10 / 否
HY-RS03361 CUL3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18472 Cul3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24953 Cul3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cul3 NCBI NCBI:8452
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