DAOA - D-amino acid oxidase activator Gene

中文名称：D-氨基酸氧化酶激活因子

种属: Homo sapiens

同用名: LG72; SG72

基因 ID: 267012 | 基因类型: protein coding

关于 DAOA

Cytogenetic location: 13q33.2 Genomic coordinates (GRCh38): 13:105,465,867-105,491,034 (from NCBI)

This gene has 11 transcripts (splice variants), 7 orthologues and is associated with 1 phenotype.

功能概要

该基因编码的蛋白质可作为 D-氨基酸氧化酶的激活剂，降解神经胶质递质 D-丝氨酸，这是一种有效的 N-甲基-D-天冬氨酸 (NMDA) 型谷氨酸受体激活剂。研究还表明，一种编码的亚型可能在线粒体功能和树突状树枝化中发挥作用。该基因的多态性与精神分裂症和双相情感障碍的易感性有关。已经识别出编码不同亚型的选择性剪接转录本变体。[RefSeq 提供，2011 年 3 月]

This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011]

DAOA 基因产物(6)

mRNA	Protein	Name
NM_001161812.1	NP_001155284.1	D-amino acid oxidase activator isoform 2
NM_001161814.1	NP_001155286.1	D-amino acid oxidase activator isoform 3
NM_001384644.1	NP_001371573.1	D-amino acid oxidase activator isoform 4
NM_001384645.1	NP_001371574.1	D-amino acid oxidase activator isoform 5
NM_001384646.1	NP_001371575.1	D-amino acid oxidase activator isoform 3
NM_172370.5	NP_758958.3	D-amino acid oxidase activator isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12364586	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in D-amino acid metabolic process	IDA IDA: 通过直接分析推断	12364586	GOA
involved in positive regulation of protein catabolic process	IDA IDA: 通过直接分析推断	21679769	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	12364586	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	17684499	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	21679769	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DAOA 蛋白结构

DAOA

0
100
153 a.a.

蛋白主名

其他名称

D-amino acid oxidase activator

schizophrenia- and bipolar disorder-associated protein G72

关联疾病

疾病名称

别名

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Schizoaffective Disorder

Schizo-Affective Psychosis	Schizo-Affective Type Schizophrenia
Schizoaffective Psychosis	Schizoaffective Schizophrenia
Schizophrenia, Schizo-Affective Type	Schizophreniform Psychosis, Affective Type

Schizophrenia 7

SCZD7	Schizophrenia Susceptibility Locus, Chromosome 13q-Related
Schizophrenia 7 With Or Without An Affective Disorder

Schizophrenia 1

SCZD1	Schizophrenia Susceptibility Locus, Chromosome 5-Related
Schizophrenia 1 With Or Without An Affective Disorder

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Cyclothymic Disorder

Cyclothymia	Cycloid Personality
Cyclothymic Personality	Affective Personality Disorder
Cyclothymic Personality Disorder	Cycloid Personality Disorder

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Schizotypal Personality Disorder

Schizotypal Personality

Bipolar I Disorder

Manic Depression Nos	Manic-Depressive Illness
Bipolar Disorder Nos

Schizophreniform Disorder

Schizophreniform Disorders

Psychotic Disorders

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DAOA - D-amino acid oxidase activator Gene

关于 DAOA

功能概要

DAOA 基因产物(6)

DAOA 蛋白结构

关联疾病

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DAOA - D-amino acid oxidase activator Gene

关于 DAOA

功能概要

DAOA 基因产物(6)

DAOA 蛋白结构

关联疾病

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热门区域

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F

G

H

J

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N

Q

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X

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