2. Gene
  3. GFER - growth factor, augmenter of liver regeneration Gene

GFER - growth factor, augmenter of liver regeneration Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：生长因子，肝再生促进因子

种属: Homo sapiens

同用名: ALR; HPO; HSS; ERV1; HPO1; HPO2; HERV1; MMCHD; MPMCD

基因 ID: 2671 | 基因类型: protein coding

关于 GFER

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,984,193-1,987,749 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and is associated with 4 phenotypes. Ubiquitous expression in small intestine (RPKM 7.8), duodenum (RPKM 7.7) and 25 other tissues.

功能概要

被指定为肝再生促进剂 (ALR) 的肝营养因子被认为是导致哺乳动物肝脏具有非凡再生能力的因素之一。它也被称为肝再生刺激物质 (HSS) 。该基因位于 16 号染色体上，位于包含多囊肾病 (PKD1) 基因座的区间内。推定的基因产物与酵母的 scERV1 蛋白有 42% 的相似性。已发现酵母 scERV1 基因对于氧化磷酸化、线粒体基因组的维持和细胞分裂周期至关重要。人类基因是酵母 scERV1 基因的结构和功能同系物。[RefSeq 提供，2008 年 7 月]

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]

GFER 基因产物(1)

mRNA Protein Name
NM_005262.3 NP_005253.3 FAD-linked sulfhydryl oxidase ALR

GFER 蛋白结构

Evr1_Alr

Evr1_Alr: Erv1 / Alr family (105 - 196)

  • 0
  • 100
  • 205 a.a.
蛋白主名 其他名称

FAD-linked sulfhydryl oxidase ALR

ERV1 homolog

重组 GFER 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70953 GFER Protein, Human (His) P55789-2 (M1-D125) ≥95%
HY-P74126 GFER Protein, Human (HEK293, His) P55789-2 (M1-D125) ≥95%

关联疾病

疾病名称 别名
Myopathy, Mitochondrial Progressive, With Congenital Cataract And Developmental Delay

Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay

Congenital Cataract-Progressive Muscular Hypotonia-Hearing Loss-Developmental Delay Syndrome

MPMCD

Myopathy With Cataract And Combined Respiratory Chain Deficiency

Mitochondrial Complex Deficiency, Combined

Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And

Myopathy With Cataract And Combined Respiratory-Chain Deficiency

Congenital Cataract-Progressive Muscular Hypotonia-Deafness-Developmental Delay Syndrome

Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss And Developmental Delay

Combined Mitochondrial Complex Deficiency
Mitochondrial Disease

Mitochondrial Diseases

Mitochondrial Disorder
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Myopathy

Muscular Diseases

Myopathies
Budd-Chiari Syndrome

Hepatic Vein Thrombosis

Chiari Syndrome

BDCHS

Membranous Obstruction Of The Inferior Vena Cava

Budd-Chiari Syndrome, Somatic

Movc

Budd-Chiari Syndrome, Susceptibility To, Somatic

Budd-Chiari Syndrome, Susceptibility To

Membranous Obstruction Of Inferior Vena Cava

Hepatic Vein Block

Obstruction Of Hepatic Veins

Hepatic Vein Obstruction

Hepatic Venous Block
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05377 GFER Human Pre-designed siRNA Set A / 否
HY-N12840 Logmalicid B / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus GFER VGNC VGNC:62521
Rattus norvegicus GFER RGD RGD:61845
Bos taurus GFER VGNC VGNC:29324
Mus musculus GFER MGD MGI:107757
Macaca mulatta GFER VGNC VGNC:104729
Others GFER NCBI
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