2. Gene
  3. STEAP1 - STEAP family member 1 Gene

STEAP1 - STEAP family member 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：STEAP 家族成员 1

种属: Homo sapiens

同用名: STEAP; PRSS24

基因 ID: 26872 | 基因类型: protein coding

关于 STEAP1

Cytogenetic location: 7q21.13 Genomic coordinates (GRCh38): 7:90,154,469-90,164,827 (from NCBI)

This gene has 3 transcripts (splice variants), 143 orthologues and 4 paralogues. Biased expression in prostate (RPKM 54.6), appendix (RPKM 20.3) and 9 other tissues.

功能概要

该基因主要在前列腺组织中表达，并被发现在多种癌细胞系中被上调。该基因产物被预测为六次跨膜蛋白，并被证明是一种在细胞-细胞连接处显着表达的细胞表面抗原。[RefSeq 提供，2008 年 7 月]

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple Cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]

STEAP1 基因产物(1)

mRNA Protein Name
NM_012449.3 NP_036581.1 metalloreductase STEAP1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables ferric-chelate reductase (NADPH) activity IDA
IDA: 通过直接分析推断
32409586 GOA
enables heme binding IDA
IDA: 通过直接分析推断
32409586 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
32409586 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STEAP1 蛋白结构

Ferric_reduct

Ferric_reduct: Ferric reductase like transmembrane component (119 - 263)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
蛋白主名 其他名称

metalloreductase STEAP1

STEAP1 metalloreductase

关联疾病

疾病名称 别名
Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia
Aceruloplasminemia

Cerebellar Ataxia

Hypoceruloplasminemia

Hemosiderosis, Systemic, Due To Aceruloplasminemia

Familial Apoceruloplasmin Deficiency

Hereditary Ceruloplasmin Deficiency

Deficiency Of Ferroxidase

Hypoceruloplasminemia, Hereditary

Ceruloplasmin Deficiency

Systemic Hemosiderosis Due To Aceruloplasminemia

ACERULOP
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P990688 Xaluritamig Inhibitor ≥99% Phase 3
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-138635 PROTAC BRD4 Degrader-12 Inhibitor 99.85% 否
HY-138634 PROTAC BRD4 Degrader-11 Inhibitor 99.45% 否
HY-138632 PROTAC BRD4 Degrader-9 Inhibitor 98.23% 否
HY-138633 PROTAC BRD4 Degrader-10 Inhibitor 99.75% 否
HY-RS13905 STEAP1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS13906 STEAP1B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16998 Steap1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23441 Steap1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990673 Vandortuzumab Inhibitor 99.00% 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus STEAP1 MGD MGI:1917608
Rattus norvegicus STEAP1 RGD RGD:1311543
Others STEAP1 NCBI
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