2. Gene
  3. Pclo - piccolo (presynaptic cytomatrix protein) Gene

Pclo - piccolo (presynaptic cytomatrix protein) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Acz; Pico

基因 ID: 26875 | 基因类型: protein coding

关于 Pclo

功能概要

Enables profilin binding activity. A structural constituent of presynaptic active zone. Involved in presynapse to nucleus signaling pathway; protein localization to synapse; and synaptic vesicle clustering. Acts upstream of or within Cytoskeleton organization; Insulin secretion; and regulation of exocytosis. Located in postsynaptic density and presynaptic active zone cytoplasmic component. Is expressed in nervous system and sensory organ. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein). [provided by Alliance of Genome Resources, Apr 2022]

Pclo 基因产物(2)

mRNA Protein Name
NM_001110796.2 NP_001104266.1 protein piccolo isoform 2
NM_011995.4 NP_036125.4 protein piccolo isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables profilin binding IDA
IDA: 通过直接分析推断
10508862 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12401793 MGI
enables structural constituent of presynaptic active zone IDA
IDA: 通过直接分析推断
26793095 MGI
enables structural constituent of presynaptic active zone IMP
IMP: 通过突变表型推断
26793095 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cytoskeleton organization IDA
IDA: 通过直接分析推断
10508862 MGI
acts upstream of or within insulin secretion IDA
IDA: 通过直接分析推断
12401793 MGI
involved in presynaptic actin cytoskeleton organization EXP
EXP: 通过实验结果推断
21976510 MGI
involved in presynaptic actin cytoskeleton organization IDA
IDA: 通过直接分析推断
21976510 MGI
involved in presynaptic actin cytoskeleton organization IMP
IMP: 通过突变表型推断
21976510 MGI
involved in protein localization to synapse IGI
IGI: 通过遗传相互作用推断
25652077 MGI
acts upstream of or within regulation of exocytosis IDA
IDA: 通过直接分析推断
12401793 MGI
involved in synaptic vesicle clustering IDA
IDA: 通过直接分析推断
20332206 MGI
involved in synaptic vesicle clustering IMP
IMP: 通过突变表型推断
20332206 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in postsynaptic density IDA
IDA: 通过直接分析推断
17114649 MGI
located in synapse IDA
IDA: 通过直接分析推断
10508862 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein piccolo

aczonin

brain-derived HLMN protein

multidomain presynaptic cytomatrix protein

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10155 PCLO Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22272 Pclo Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28795 Pclo Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pclo NCBI NCBI:27445
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