2. Gene
  3. Foxl2 - forkhead box L2 Gene

Foxl2 - forkhead box L2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: BPES; Pfrk; PINTO

基因 ID: 26927 | 基因类型: protein coding

关于 Foxl2

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and Estrogen receptor binding activity. Acts upstream of or within several processes, including positive regulation of gonadotropin secretion; regulation of transcription by RNA polymerase II; and reproductive structure development. Located in nucleus. Is expressed in several structures, including adenohypophysis; branchial arch; eye; future pituitary; and genitourinary system. Used to study blepharophimosis, ptosis, and epicanthus inversus syndrome. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome and primary ovarian insufficiency 3. Orthologous to human FOXL2 (forkhead box L2). [provided by Alliance of Genome Resources, Apr 2022]

Foxl2 基因产物(1)

mRNA Protein Name
NM_012020.2 NP_036150.1 forkhead box protein L2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
12943993 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
12943993 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
12943993 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12943993 MGI
enables nuclear estrogen receptor binding IPI
IPI: 通过物理相互作用推断
19797124 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16153597 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within embryonic eye morphogenesis IMP
IMP: 通过突变表型推断
15056605 MGI
acts upstream of or within female gonad development IGI
IGI: 通过遗传相互作用推断
24739304 MGI
acts upstream of or within female somatic sex determination IMP
IMP: 通过突变表型推断
15944199 MGI
acts upstream of or within granulosa cell differentiation IMP
IMP: 通过突变表型推断
14736745 MGI
acts upstream of or within negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
21757499 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
21757499 MGI
acts upstream of or within ovarian follicle development IGI
IGI: 通过遗传相互作用推断
24739304 MGI
acts upstream of or within ovarian follicle development IMP
IMP: 通过突变表型推断
14736745 MGI
acts upstream of or within positive regulation of follicle-stimulating hormone secretion IGI
IGI: 通过遗传相互作用推断
24739304 MGI
acts upstream of or within positive regulation of luteinizing hormone secretion IGI
IGI: 通过遗传相互作用推断
24739304 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12943993 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
24739304 MGI
acts upstream of or within single fertilization IGI
IGI: 通过遗传相互作用推断
24739304 MGI
acts upstream of or within uterus development IGI
IGI: 通过遗传相互作用推断
24739304 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
15056605 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

forkhead box protein L2

P-Frk

pituitary forkhead factor

putative transcription factor foxl2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05062 FOXL2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20023 Foxl2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26526 Foxl2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Foxl2 NCBI NCBI:668
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