2. Gene
  3. Megf8 - multiple EGF-like-domains 8 Gene

Megf8 - multiple EGF-like-domains 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Egfl4; m687Ddg; b2b288Clo; mKIAA0817; b2b1702Clo; b2b1702.2Clo

基因 ID: 269878 | 基因类型: protein coding

关于 Megf8

功能概要

Predicted to enable calcium ion binding activity. Involved in several processes, including embryonic organ development; generation of neurons; and negative regulation of smoothened signaling pathway. Acts upstream of or within coronary vasculature development; determination of digestive tract left/right asymmetry; and determination of heart left/right asymmetry. Located in nucleus. Is expressed in several structures, including branchial arch; ganglia; heart; limb bud; and telencephalon. Used to study Carpenter syndrome and visceral heterotaxy. Human ortholog(s) of this gene implicated in Carpenter syndrome. Orthologous to human MEGF8 (multiple EGF like domains 8). [provided by Alliance of Genome Resources, Apr 2022]

Megf8 基因产物(1)

mRNA Protein Name
NM_001160400.1 NP_001153872.1 multiple epidermal growth factor-like domains protein 8 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32966817 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
24052814 MGI
acts upstream of or within aorta development IMP
IMP: 通过突变表型推断
32203821 MGI
acts upstream of or within coronary vasculature development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within determination of digestive tract left/right asymmetry IMP
IMP: 通过突变表型推断
18043505 MGI
acts upstream of or within determination of heart left/right asymmetry IMP
IMP: 通过突变表型推断
18043505 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within embryonic brain development IMP
IMP: 通过突变表型推断
32203821 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: 通过突变表型推断
32203821 MGI
involved in embryonic heart tube left/right pattern formation IMP
IMP: 通过突变表型推断
24052814 MGI
involved in embryonic heart tube morphogenesis IMP
IMP: 通过突变表型推断
24052814 MGI
involved in embryonic limb morphogenesis IMP
IMP: 通过突变表型推断
24052814 MGI
involved in embryonic skeletal system morphogenesis IMP
IMP: 通过突变表型推断
24052814 MGI
NOT acts upstream of or within epithelial cilium movement involved in determination of left/right asymmetry IMP
IMP: 通过突变表型推断
18043505 MGI
involved in fasciculation of sensory neuron axon IMP
IMP: 通过突变表型推断
24052814 MGI
acts upstream of or within heart development IGI
IGI: 通过遗传相互作用推断
32966817 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
32203821 MGI
acts upstream of or within left/right pattern formation IMP
IMP: 通过突变表型推断
32203821 MGI
involved in left/right pattern formation IMP
IMP: 通过突变表型推断
24052814 MGI
acts upstream of or within limb development IMP
IMP: 通过突变表型推断
32966817 MGI
involved in negative regulation of smoothened signaling pathway IMP
IMP: 通过突变表型推断
29290584 MGI
acts upstream of or within pharyngeal arch artery morphogenesis IMP
IMP: 通过突变表型推断
32203821 MGI
involved in positive regulation of axon extension involved in axon guidance IMP
IMP: 通过突变表型推断
24052814 MGI
acts upstream of or within protein ubiquitination IDA
IDA: 通过直接分析推断
32966817 MGI
acts upstream of or within protein ubiquitination IMP
IMP: 通过突变表型推断
32966817 MGI
acts upstream of or within protein-containing complex assembly IDA
IDA: 通过直接分析推断
32966817 MGI
acts upstream of or within protein-containing complex assembly IMP
IMP: 通过突变表型推断
32966817 MGI
involved in regulation of gene expression IMP
IMP: 通过突变表型推断
24052814 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: 通过突变表型推断
32966817 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
NOT located in membrane IDA
IDA: 通过直接分析推断
19218456 MGI
located in nucleus IDA
IDA: 通过直接分析推断
19218456 MGI
part of ubiquitin ligase complex IDA
IDA: 通过直接分析推断
32966817 MGI
part of ubiquitin ligase complex IPI
IPI: 通过物理相互作用推断
32966817 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

multiple epidermal growth factor-like domains protein 8

EGF-like protein 4

EGF-like-domain, multiple 4

epidermal growth factor-like protein 4

multiple EGF-like domains protein 8

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08317 MEGF8 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19022 Megf8 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25511 Megf8 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Megf8 NCBI NCBI:1954
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