Idh2 - isocitrate dehydrogenase 2 (NADP+), mitochondrial Gene

中文名称：异柠檬酸脱氢酶 2 (NADP+) ，线粒体

种属: Mus musculus

同用名: IDPm; Idh-2; E430004F23

关于 Idh2

功能概要

该基因编码的蛋白可启动异柠檬酸脱氢酶 (NADP+) 活性。预计参与多个过程，包括NADP生物合成过程；异柠檬酸代谢过程；基质金属肽酶分泌的负调控。预计在乙醛酸循环和三羧酸循环的上游或内部起作用。位于胞质溶胶和过氧化物酶体中。以多种结构表达，包括消化系统；脑;泌尿生殖系统；呼吸系统;和感觉器官。涉及 D-2-羟基戊二酸尿症 2 的该基因的人类直系同源物；急性髓性白血病；癌（多发性）；和肺癌（多发）。与人类 IDH2（异柠檬酸脱氢酶 (NADP(+)) 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in several processes, including NADP biosynthetic process; isocitrate metabolic process; and negative regulation of matrix metallopeptidase secretion. Predicted to act upstream of or within glyoxylate cycle and tricarboxylic acid cycle. Located in cytosol and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung Cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2). [provided by Alliance of Genome Resources, Apr 2022]