TJP3 - tight junction protein 3 Gene

中文名称：紧密连接蛋白 3

种属: Homo sapiens

同用名: ZO3; ZO-3

关于 TJP3

功能概要

由该基因编码的蛋白质是膜相关鸟苷酸激酶样 (MAGUK) 蛋白家族的成员，其特征是成员具有多个 PDZ 结构域、单个 SH3 结构域和单个鸟苷酸激酶样 (GUK) 结构域.此外，zonula occludens 蛋白亚家族的成员有一个酸性结构域、一个富含碱性精氨酸的区域和一个富含脯氨酸的结构域。由该基因编码的蛋白质在肌动蛋白细胞骨架和紧密连接之间的联系中发挥作用，并且还在有丝分裂期间在紧密连接处隔离细胞周期蛋白 D1。可变剪接导致编码不同异构体的多个转录变体。该基因在 1 号染色体上有一个部分假基因。[RefSeq 提供，2012 年 5 月]

The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin Cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during Mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]