SIGLEC8 - sialic acid binding Ig like lectin 8 Gene

中文名称：唾液酸结合 Ig 样凝集素 8

种属: Homo sapiens

同用名: SAF2; SIGLEC-8; SIGLEC8L

关于 SIGLEC8

功能概要

唾液酸结合免疫球蛋白 (Ig) 样凝集素或 Siglec (例如，CD33 (MIM 159590) ) 是 1 型跨膜蛋白家族，每种跨膜蛋白均具有独特的表达模式，主要存在于造血细胞中。 SIGLEC8 是 Siglec 的 CD33 样亚组的成员，其定位于 19q13.3-q13.4 并具有 2 个基于细胞质酪氨酸的保守基序：基于免疫受体酪氨酸的抑制基序或 ITIM (参见 MIM 604964) ，以及与信号淋巴细胞激活分子 (SLAM；MIM 603492) 中鉴定的基序同源的基序，它介导与 SLAM 相关蛋白 (SAP；MIM 300490) 的关联 (由 Foussias 等人总结，2000 [PubMed 11095983]) 。[提供 OMIM，2010 年 5 月]

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]