PDCD4 - programmed cell death 4 Gene

中文名称：程序性细胞死亡 4

种属: Homo sapiens

同用名: H731

基因 ID: 27250 | 基因类型: protein coding

关于 PDCD4

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:110,871,928-110,900,006 (from NCBI)

This gene has 11 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in colon (RPKM 80.4), thyroid (RPKM 70.8) and 25 other tissues.

功能概要

该基因是一种肿瘤抑制基因，编码一种与真核翻译起始因子 4A1 结合并通过阻止 RNA 结合来抑制其功能的蛋白质。可变剪接导致多个转录本变体。[RefSeq 提供，2010 年 12 月]

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

PDCD4 基因产物(3)

mRNA	Protein	Name
NM_001199492.2	NP_001186421.1	programmed cell death protein 4 isoform 3
NM_014456.5	NP_055271.2	programmed cell death protein 4 isoform 1
NM_145341.4	NP_663314.1	programmed cell death protein 4 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12054647	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in BMP signaling pathway	IDA IDA: 通过直接分析推断	18548003	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	16357133	GOA
involved in negative regulation of myofibroblast differentiation	IMP IMP: 通过突变表型推断	20533548	GOA
involved in negative regulation of vascular associated smooth muscle cell differentiation	IDA IDA: 通过直接分析推断	18548003	GOA
involved in negative regulation of vascular associated smooth muscle cell proliferation	IMP IMP: 通过突变表型推断	28522568	GOA
involved in positive regulation of endothelial cell apoptotic process	IMP IMP: 通过突变表型推断	24732886	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	19946272	GOA
involved in positive regulation of vascular associated smooth muscle cell apoptotic process	IMP IMP: 通过突变表型推断	28522568	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IMP IMP: 通过突变表型推断	16357133	GOA
located in cytosol	IDA IDA: 通过直接分析推断	12054647	GOA
located in nucleus	IMP IMP: 通过突变表型推断	16357133	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDCD4 蛋白结构

MA3

0
100
200
300
400
469 a.a.

蛋白主名

其他名称

programmed cell death protein 4

neoplastic transformation inhibitor protein

PDCD4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PDCD4	Q53EL6	APOE	Homo sapiens	P02649	Anti Bait CoIP	21163940
种属内	PDCD4	Q53EL6	EIF4A3	Homo sapiens	P38919	Y2H Prey Pooling	32296183
种属内	PDCD4	Q53EL6	EIF4A3	Homo sapiens	P38919	Validated Y2H	25416956
种属内	PDCD4	Q53EL6	EIF4A3	Homo sapiens	P38919	Y2H Array	25416956
种属内	PDCD4	Q53EL6	EIF4A3	Homo sapiens	P38919	Y2H Array	32296183
种属内	PDCD4	Q53EL6	RPS13	Homo sapiens	P62277	Y2H	12054647
种属内	PDCD4	Q53EL6	EIF4A1	Homo sapiens	P60842	Anti Bait CoIP	24413684
种属内	PDCD4	Q53EL6	EIF4A2	Homo sapiens	Q14240	Anti Bait CoIP	17353931
种属内	PDCD4	Q53EL6	EIF4A2	Homo sapiens	Q14240	Validated Y2H	25416956
种属内	PDCD4	Q53EL6	EIF4A2	Homo sapiens	Q14240	Y2H Array	25416956
种属内	PDCD4	Q53EL6	RELA	Homo sapiens	Q04206	Anti Tag CoIP	24413684
种属内	PDCD4	Q53EL6	RELA	Homo sapiens	Q04206	Anti Bait CoIP	24413684

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PDCD4 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71191	PDCD4 Protein, Human (His)	Q53EL6 (K212-P357)	≥95%

PDCD4 抗体

目录号	产品名	应用	反应物种
HY-P80269	PDCD4 Antibody (YA240)	WB, ICC/IF, IHC-P, FC	Human, Mouse

关联疾病

疾病名称

别名

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Ciliary Dyskinesia, Primary, 30

Primary Ciliary Dyskinesia 30	CILD30
Ciliary Dyskinesia, Primary, 30, With Or Without Situs Inversus	Primary Ciliary Dyskinesia 30 Without Situs Inversus
Primary Ciliary Dyskinesia 30 With Or Without Situs Inversus	Dyskinesia, Ciliary, Primary, Type 30

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-145232	PhosTAC7		98.76%	否
HY-148508	PhosTAC3		99.97%	否
HY-148509	PhosTAC5		98.02%	否
HY-153383	PDCD4-IN-1		99.41%	否
HY-RS10192	PDCD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17345	Pdcd4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23799	Pdcd4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	PDCD4	VGNC	VGNC:75794
Rattus norvegicus	PDCD4	RGD	RGD:620816
Mus musculus	PDCD4	MGD	MGI:107490
Felis catus	PDCD4	VGNC	VGNC:68744
Bos taurus	PDCD4	VGNC	VGNC:32661
Canis familiaris	PDCD4	VGNC	VGNC:44338
Others	PDCD4	NCBI

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站点地图隐私声明

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PDCD4 - programmed cell death 4 Gene

关于 PDCD4

功能概要

PDCD4 基因产物(3)

PDCD4 蛋白结构

PDCD4 蛋白互作信息

重组 PDCD4 蛋白

PDCD4 抗体

关联疾病

直系同源

热门区域

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PDCD4 - programmed cell death 4 Gene

关于 PDCD4

功能概要

PDCD4 基因产物(3)

PDCD4 蛋白结构

PDCD4 蛋白互作信息

重组 PDCD4 蛋白

PDCD4 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z