2. Gene
  3. TINAG - tubulointerstitial nephritis antigen Gene

TINAG - tubulointerstitial nephritis antigen Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肾小管间质性肾炎抗原

种属: Homo sapiens

同用名: TIN-AG

基因 ID: 27283 | 基因类型: protein coding

关于 TINAG

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:54,307,862-54,390,142 (from NCBI)

This gene has 4 transcripts (splice variants), 285 orthologues and 12 paralogues. Biased expression in kidney (RPKM 36.8), colon (RPKM 4.4) and 2 other tissues.

功能概要

该基因编码一种糖蛋白，该糖蛋白仅限于肾脏内鲍曼氏囊和近端和远端小管上皮下的基底膜。在肾小管间质性肾炎、膜性肾病和抗肾小球基底膜肾炎患者的血清中发现了针对该蛋白的自身抗体。个体发育研究表明，该抗原的表达在整个肾发生过程中以精确的空间和时间模式进行发育调节。[RefSeq 提供，2011 年 11 月]

This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]

TINAG 基因产物(1)

mRNA Protein Name
NM_014464.4 NP_055279.3 tubulointerstitial nephritis antigen
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell adhesion IDA
IDA: 通过直接分析推断
8770961 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basement membrane IDA
IDA: 通过直接分析推断
1762287 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TINAG 蛋白结构

Somatomedin_B

Somatomedin_B: Somatomedin B domain (60 - 106)

Peptidase_C1

Peptidase_C1: Papain family cysteine protease (236 - 464)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
蛋白主名 其他名称

tubulointerstitial nephritis antigen

关联疾病

疾病名称 别名
Membranous Nephropathy

Membranous Glomerulonephritis

Glomerulonephritis, Membranous

Idiopathic Membranous Nephropathy

Idiopathic Membranous Glomerulonephritis

MBNP

Membranous Nephropathy, Susceptibility To

Extramembranous Glomerulonephritis

Mgn

Membranous Gn

Primary Membranous Glomerulonephritis

Primary Membranous Nephropathy

Nephropathy Membranous
Interstitial Nephritis

Nephritis, Interstitial

Renal Tubulo-Interstitial Disease

Nephritis Interstitial

Nephritis, Tubulointerstitial
Tinea Barbae

Dermatophytosis Of Beard
Tinea Imbricata

Kerion Celsi

Trichophyton Infection

Tinea Imbricata, Susceptibility To

Susceptibility To Tinea Imbricata

Tinea Capitis Profunda

Trichophytia Profunda Barbae

Trichophytia Profunda Capitis

Tinea Capitis
Tinea Manuum

Tinea Manus

Dermatophytosis Of Hand
Tinea Cruris

Dermatophytosis Of Groin & Perianal Area

Dermatophytosis Of Groin And Perianal Area

Dhobie Itch

Tinea Of Perianal Region
Tinea Unguium

Dermatophytosis Of Nail

Onychomycosis Due To Dermatophyte

Cellulitis And Abscess

Cellulitis And Abscess Of Buttock

Cellulitis And Abscess Of Face

Cellulitis And Abscess Of Finger

Cellulitis And Abscess Of Finger And Toe

Cellulitis And Abscess Of Gluteal Region

Cellulitis And Abscess Of Trunk

Cellulitis And Abscess Of Upper Arm And Forearm

Dermatophytic Onychia

Dermatophytic Onychomycosis

Onychomycosis

Ringworm Of Nails

Tinea Of Nail
Tinea Corporis

Dermatophytosis Of The Body

Dermatophytosis Of The Trunk
Tinea Capitis

Dermatophytosis Of Scalp

Scalp Ringworm

Dermatophytosis Of Scalp Or Beard

Tinea Capitis Due To Trichophyton Rubrum

Trichophyton Rubrum Tinea Capitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14542 TINAG Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20116 Tinag Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26620 Tinag Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TINAG VGNC VGNC:35874
Rattus norvegicus TINAG RGD RGD:1359482
Canis familiaris TINAG VGNC VGNC:47379
Mus musculus TINAG MGD MGI:1349477
Felis catus TINAG VGNC VGNC:66195
Macaca mulatta TINAG VGNC VGNC:78382
Others TINAG NCBI
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