2. Gene
  3. MCAT - malonyl-CoA-acyl carrier protein transacylase Gene

MCAT - malonyl-CoA-acyl carrier protein transacylase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丙二酰辅酶 A 酰基载体蛋白转酰基酶

种属: Homo sapiens

同用名: MT; MCT; MCT1; fabD; NET62; FASN2C

基因 ID: 27349 | 基因类型: protein coding

关于 MCAT

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:43,132,206-43,143,398 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 9.6), testis (RPKM 4.7) and 25 other tissues.

功能概要

由该基因编码的蛋白质仅存在于线粒体中，在那里它催化丙二酰基从丙二酰辅酶 A 转移到线粒体酰基载体蛋白。编码的蛋白质可能是脂肪酸合酶复合物的一部分，它更像是 II 型原核和质体复合物，而不是 I 型人胞质复合物。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 3 月]

The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]

MCAT 基因产物(2)

mRNA Protein Name
NM_014507.3 NP_055322.1 malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform b precursor
NM_173467.5 NP_775738.3 malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables [acyl-carrier-protein] S-malonyltransferase activity IDA
IDA: 通过直接分析推断
12882974 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in fatty acid biosynthetic process IDA
IDA: 通过直接分析推断
12882974 GOA
involved in mitochondrial small ribosomal subunit assembly IDA
IDA: 通过直接分析推断
36482135 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
12882974 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MCAT 蛋白结构

Acyl_transf_1

Acyl_transf_1: Acyl transferase domain (64 - 336)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
蛋白主名 其他名称

malonyl-CoA-acyl carrier protein transacylase, mitochondrial

[Acyl-carrier-protein] malonyltransferase

关联疾病

疾病名称 别名
Autosomal Recessive Isolated Optic Atrophy

Autosomal Recessive Non-Syndromic Optic Atrophy
Optic Atrophy 6

OPA6

Optic Atrophy, Congenital Or Early Infantile, Autosomal Recessive
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-15533 LY 3000328 Inhibitor 99.50% Phase 1
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08216 MCAT Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS21371 Mcat Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS27890 Mcat Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MCAT VGNC VGNC:43069
Felis catus MCAT VGNC VGNC:63410
Macaca mulatta MCAT VGNC VGNC:74616
Mus musculus MCAT MGD MGI:2388651
Rattus norvegicus MCAT RGD RGD:1306698
Bos taurus MCAT VGNC VGNC:31297
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