GNGT1 - G protein subunit gamma transducin 1 Gene

中文名称：G 蛋白亚基γ转导蛋白 1

种属: Homo sapiens

同用名: GNG1; HG3G1

基因 ID: 2792 | 基因类型: protein coding

关于 GNGT1

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,906,567-93,911,265 (from NCBI)

This gene has 5 transcripts (splice variants), 143 orthologues and 11 paralogues. Restricted expression toward placenta (RPKM 1.6).

功能概要

该基因编码转导蛋白的 γ 亚基，转导蛋白是一种存在于视杆外段的鸟嘌呤核苷酸结合蛋白 (G 蛋白) 。转导蛋白，也称为 GMPase，介导视紫红质对环 GTP 特异性 (鸟苷一磷酸) 磷酸二酯酶的激活。[RefSeq 提供，2016 年 7 月]

This gene encodes the gamma subunit of transducin, a guanine nucleotide-binding protein (G protein) that is found in rod outer segments. Transducin, also known as GMPase, mediates the activation of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase by rhodopsin. [provided by RefSeq, Jul 2016]

GNGT1 基因产物(2)

mRNA	Protein	Name
NM_001329426.2	NP_001316355.1	guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor
NM_021955.5	NP_068774.1	guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GNGT1 蛋白结构

G-gamma

0
74 a.a.

蛋白主名

其他名称

guanine nucleotide-binding protein G(T) subunit gamma-T1

guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1

GNGT1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GNGT1	P63211	ZNF277	Homo sapiens	Q8WWA6	Y2H Prey Pooling	25416956
种属内	GNGT1	P63211	ZNF277	Homo sapiens	G5E9M4	Y2H Prey Pooling	32296183
种属内	GNGT1	P63211	ZNF277	Homo sapiens	G5E9M4	Y2H Array	32296183
种属内	GNGT1	P63211	PDCL	Homo sapiens	Q13371	Anti Tag CoIP	33961781
种属内	GNGT1	P63211	UBXN4	Homo sapiens	Q92575	Y2H Prey Pooling	32296183
种属内	GNGT1	P63211	UBXN4	Homo sapiens	Q92575	Validated Y2H	32296183
种属内	GNGT1	P63211	UBXN4	Homo sapiens	Q92575	Y2H Array	32296183
种属内	GNGT1	P63211	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
种属内	GNGT1	P63211	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
种属内	GNGT1	P63211	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
种属内	GNGT1	P63211	MSANTD4	Homo sapiens	Q8NCY6	Validated Y2H	32296183
种属内	GNGT1	P63211	MSANTD4	Homo sapiens	Q8NCY6	Y2H Array	32296183
种属内	GNGT1	P63211	MSANTD4	Homo sapiens	Q8NCY6	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GNGT1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76369	GNGT1 Protein, Human (His)	P63211 (P2-C71)	≥95%

关联疾病

疾病名称

别名

Night Blindness, Congenital Stationary, Autosomal Dominant 2

Congenital Stationary Night Blindness Autosomal Dominant 2	CSNBAD2
Hemeralopia	Night Blindness, Congenital Stationary, Rambusch Type
Rambusch Type Congenital Stationary Night Blindness	Congenital Stationary Night Blindness Rambusch Type
Hemeralopia Congenital Essential	Blindness, Night, Stationary, Congenital, Autosomal Dominant, Type 2

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05562	GNGT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS19436	Gngt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25927	Gngt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	GNGT1	VGNC	VGNC:73098
Mus musculus	GNGT1	MGD	MGI:109165
Felis catus	GNGT1	VGNC	VGNC:62624
Bos taurus	GNGT1	VGNC	VGNC:29470
Rattus norvegicus	GNGT1	RGD	RGD:1595475
Canis familiaris	GNGT1	VGNC	VGNC:41324
Others	GNGT1	NCBI

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