SELENOH - selenoprotein H Gene

中文名称：硒蛋白 H

种属: Homo sapiens

同用名: SELH; C11orf31; C17orf10

关于 SELENOH

功能概要

该基因编码属于 SelWTH 家族的核仁蛋白。它作为一种氧化还原酶发挥作用，并已被证明可以通过抑制凋亡细胞死亡途径保护神经元免受 UVB 诱导的损伤，促进线粒体生物发生和线粒体功能，并通过基因组维持和氧化还原调节抑制细胞衰老。这种蛋白质是一种硒蛋白，在其活性位点含有稀有氨基酸硒代半胱氨酸 (Sec) 。 Sec 由 UGA 密码子编码，通常表示翻译终止。硒蛋白 mRNA 的 3' UTR 包含一个保守的茎环结构，称为 Sec 插入序列 (SECIS) 元件，这是将 UGA 识别为 Sec 密码子而不是终止信号所必需的。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2016 年 5 月]

This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]