GPD1 - glycerol-3-phosphate dehydrogenase 1 Gene

中文名称：3-磷酸甘油脱氢酶 1

种属: Homo sapiens

同用名: GPD-C; HTGTI; GPDH-C

基因 ID: 2819 | 基因类型: protein coding

关于 GPD1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,104,008-50,111,313 (from NCBI)

This gene has 7 transcripts (splice variants), 275 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in fat (RPKM 448.5), kidney (RPKM 83.8) and 3 other tissues.

功能概要

该基因编码 NAD 依赖性甘油 3-磷酸脱氢酶家族的成员。编码的蛋白质通过催化磷酸二羟基丙酮 (DHAP) 和还原型尼古丁腺嘌呤二核苷酸 (NADH) 向甘油-3-磷酸 (G3P) 和 NAD+ 的可逆转化，在碳水化合物和脂质代谢中发挥关键作用。编码的胞质蛋白和线粒体甘油 3-磷酸脱氢酶也形成甘油磷酸穿梭机，促进还原当量从胞质溶胶转移到线粒体。该基因的突变是暂时性婴儿高甘油三酯血症的一个原因。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 3 月]

This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

GPD1 基因产物(2)

mRNA	Protein	Name
NM_001257199.2	NP_001244128.1	glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 2
NM_005276.4	NP_005267.2	glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 1

GPD1 蛋白结构

NAD_Gly3P_dh_N

NAD_Gly3P_dh_C

0
100
200
300
349 a.a.

蛋白主名

其他名称

glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

epididymis secretory sperm binding protein

重组 GPD1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70320	GPD1 Protein, Human (HEK293, His)	P21695 (M1-M349)	≥95%

关联疾病

疾病名称

别名

Hypertriglyceridemia, Transient Infantile

Transient Infantile Hypertriglyceridemia And Hepatosteatosis	HTGTI
Transient Infantile Hypertriglyceridemia And Fatty Liver	Hypertriglyceridemia

Brugada Syndrome 2

BRGDA2

Brugada Syndrome, Type 2

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Brugada Syndrome 1

BRGDA1	Sudden Unexplained Nocturnal Death Syndrome
Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome	Sunds
Brugada Syndrome, Type 1	Brugada Syndrome

Cryptococcal Meningitis

Meningitis, Cryptococcal

Meningitis Cryptococcal

Cryptococcosis

Cryptococcus Neoformans Infection	Torulosis
Busse-Buschke'S Disease	Cryptococcal Infection
European Cryptococcosis	Torula
Infection By Cryptococcus Neoformans	Cryptococcosis Infection
European Blastomycosis	European Blastomycotic Infection
European Blastomycoses Infection	Torula Histolytica Infection

Fungal Meningitis

Meningitis, Fungal

Mycotic Meningitis

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05633	GPD1 Human Pre-designed siRNA Set A		/	否
HY-RS05634	GPD1L Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	GPD1	MGD	MGI:95679
Felis catus	GPD1	VGNC	VGNC:67407
Canis familiaris	GPD1	VGNC	VGNC:41376
Rattus norvegicus	GPD1	RGD	RGD:621381
Bos taurus	GPD1	VGNC	VGNC:29529
Others	GPD1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

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GPD1 - glycerol-3-phosphate dehydrogenase 1 Gene

关于 GPD1

功能概要

GPD1 基因产物(2)

GPD1 蛋白结构

重组 GPD1 蛋白

关联疾病

直系同源

热门区域

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GPD1 - glycerol-3-phosphate dehydrogenase 1 Gene

关于 GPD1

功能概要

GPD1 基因产物(2)

GPD1 蛋白结构

重组 GPD1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z