2. Gene
  3. SLCO3A1 - solute carrier organic anion transporter family member 3A1 Gene

SLCO3A1 - solute carrier organic anion transporter family member 3A1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体有机阴离子转运蛋白家族成员 3A1

种属: Homo sapiens

同用名: OATPD; OATP-D; OATP3A1; OATPRP3; OATP-RP3; SLC21A11

基因 ID: 28232 | 基因类型: protein coding

关于 SLCO3A1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:91,853,708-92,172,435 (from NCBI)

This gene has 13 transcripts (splice variants), 264 orthologues and 10 paralogues. Broad expression in testis (RPKM 11.4), lung (RPKM 6.4) and 23 other tissues.

功能概要

预计可实现不依赖钠的有机阴离子跨膜转运蛋白活性。参与 NF-kappaB 转录因子活性的正调控；蛋白质磷酸化的正调节；和前列腺素运输。位于质膜。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable sodium-independent organic anion transmembrane transporter activity. Involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of protein phosphorylation; and prostaglandin transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLCO3A1 基因产物(2)

mRNA Protein Name
NM_001145044.1 NP_001138516.1 solute carrier organic anion transporter family member 3A1 isoform 2
NM_013272.4 NP_037404.2 solute carrier organic anion transporter family member 3A1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables organic anion transmembrane transporter activity IDA
IDA: 通过直接分析推断
10873595 GOA
enables prostaglandin transmembrane transporter activity IDA
IDA: 通过直接分析推断
10873595 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
24945726 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
24945726 GOA
involved in prostaglandin transport IDA
IDA: 通过直接分析推断
14631946 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basal plasma membrane IDA
IDA: 通过直接分析推断
35307651 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
21278488 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLCO3A1 蛋白结构

OATP

OATP: Organic Anion Transporter Polypeptide (OATP) family (39 - 623)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (477 - 527)

  • 0
  • 200
  • 400
  • 600
  • 710 a.a.
蛋白主名 其他名称

solute carrier organic anion transporter family member 3A1

PGE1 transporter

关联疾病

疾病名称 别名
Intestinal Perforation

Perforation Of Intestine
Primary Hypertrophic Osteoarthropathy

Pachydermoperiostosis Syndrome

Osteoarthropathy, Primary Hypertrophic

Pachydermoperiostosis Of Nail

Idiopathic Hypertrophic Osteoarthropathy

Pho
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13357 SLCO3A1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SLCO3A1 RGD RGD:620227
Felis catus SLCO3A1 VGNC VGNC:65446
Canis familiaris SLCO3A1 VGNC VGNC:46497
Macaca mulatta SLCO3A1 VGNC VGNC:77598
Bos taurus SLCO3A1 VGNC VGNC:34953
Mus musculus SLCO3A1 MGD MGI:1351867
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