1. Gene
  2. ATG9B - autophagy related 9B Gene

ATG9B - autophagy related 9B Gene

中文名称:自噬相关 9B

种属: Homo sapiens

同用名: SONE; APG9L2; NOS3AS

基因 ID: 285973 | 基因类型: protein coding

关于 ATG9B

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,012,209-151,024,499 (from NCBI)

This gene has 11 transcripts (splice variants), 183 orthologues and 1 paralogue. Broad expression in skin (RPKM 9.1), placenta (RPKM 8.7) and 15 other tissues.

功能概要

该基因在调节自噬 (一种溶酶体降解途径) 中发挥作用。该基因还在内皮一氧化氮合酶 3 基因的转录后调节中起反义转录物的作用,该基因与该基因在相反链上有 3' 重叠。该基因的突变和自噬过程的破坏与多种癌症有关。可变剪接导致多个转录本变体。[RefSeq 提供,2012 年 9 月]

This gene functions in the regulation of Autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the Autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

ATG9B 基因产物(1)

mRNA Protein Name
NM_001317056.2 NP_001303985.1 autophagy-related protein 9B
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within autophagosome assembly IDA
IDA: 通过直接分析推断
15755735 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ATG9B 蛋白结构

APG9

APG9: Autophagy protein Apg9 (322 - 683)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 923 a.a.
蛋白主名 其他名称

autophagy-related protein 9B

APG9-like 2

关联疾病

疾病名称 别名
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ATG9B MGD MGI:2685420
Bos taurus ATG9B VGNC VGNC:26263
Macaca mulatta ATG9B VGNC VGNC:108389
Rattus norvegicus ATG9B RGD RGD:1560887
Felis catus ATG9B VGNC VGNC:60007
Others ATG9B NCBI