CRKL - Crkl CRK like proto-oncogene, adaptor protein Gene

种属: Rattus norvegicus

关于 CRKL

功能概要

Predicted to enable several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of substrate adhesion-dependent cell spreading; and regulation of protein phosphorylation. Predicted to act upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and generation of neurons. Located in cytoplasm. Human ortholog(s) of this gene implicated in chronic myeloid leukemia. Orthologous to human CRKL (CRK like proto-oncogene, adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]