2. Gene
  3. NOB1 - NIN1 (RPN12) binding protein 1 homolog Gene

NOB1 - NIN1 (RPN12) binding protein 1 homolog Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NIN1 (RPN12) 结合蛋白 1 同系物

种属: Homo sapiens

同用名: ART-4; NOB1P; MST158; MSTP158; PSMD8BP1

基因 ID: 28987 | 基因类型: protein coding

关于 NOB1

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:69,741,871-69,754,926 (from NCBI)

This gene has 6 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in ovary (RPKM 29.6), thyroid (RPKM 20.5) and 25 other tissues.

功能概要

在酵母中，核糖体组装需要超过 200 种蛋白质和 RNA 辅助因子，这些在真核生物中通常是保守的。这些因素协调将初始 35S 前体 rRNA 转录物修饰和切割成成熟的 18S、5.8S 和 25S rRNA、rRNA 折叠以及核糖体蛋白和 5S RNA 的结合。 Nob1 参与前 rRNA 加工。在细胞质后期加工步骤中，Nob1 在切割位点 D 切割 20S rRNA 中间体以产生成熟的 18S rRNA (Lamanna 和 Karbstein，2009 [PubMed 19706509]) 。[OMIM 提供，2010 年 11 月]

In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]

NOB1 基因产物(1)

mRNA Protein Name
NM_014062.3 NP_054781.1 RNA-binding protein NOB1

NOB1 蛋白结构

WRNPLPNID

WRNPLPNID: Putative WW-binding domain and destruction box (137 - 220)

NOB1_Zn_bind

NOB1_Zn_bind: Nin one binding (NOB1) Zn-ribbon like (260 - 332)

  • 0
  • 100
  • 200
  • 300
  • 412 a.a.
蛋白主名 其他名称

RNA-binding protein NOB1

NIN1/PSMD8 binding protein 1 homolog

关联疾病

疾病名称 别名
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09398 NOB1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NOB1 VGNC VGNC:43872
Rattus norvegicus NOB1 RGD RGD:735222
Bos taurus NOB1 VGNC VGNC:32144
Mus musculus NOB1 MGD MGI:1914869
Macaca mulatta NOB1 VGNC VGNC:99528
Others NOB1 NCBI
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