GRM3 - glutamate metabotropic receptor 3 Gene

中文名称：谷氨酸代谢型受体 3

种属: Homo sapiens

同用名: GLUR3; mGlu3; GPRC1C; MGLUR3

基因 ID: 2913 | 基因类型: protein coding

关于 GRM3

Cytogenetic location: 7q21.11-q21.12 Genomic coordinates (GRCh38): 7:86,643,909-86,864,879 (from NCBI)

This gene has 5 transcripts (splice variants), 215 orthologues, 7 paralogues and is associated with 88 phenotypes. Restricted expression toward brain (RPKM 15.9).

功能概要

L-谷氨酸是中枢神经系统中主要的兴奋性神经递质，可激活离子型和代谢型谷氨酸受体。谷氨酸能神经传递涉及正常大脑功能的大多数方面，并且在许多神经病理学状况下可能受到干扰。代谢型谷氨酸受体是 G 蛋白偶联受体家族，根据序列同源性、推定的信号转导机制和药理学特性将其分为 3 组。 I 组包括 GRM1 和 GRM5，这些受体已显示可激活磷脂酶 C。II 组包括 GRM2 和 GRM3，而 III 组包括 GRM4、GRM6、GRM7 和 GRM8。 II 组和 III 组受体与环 AMP 级联的抑制有关，但它们的激动剂选择性不同。[RefSeq 提供，2008 年 7 月]

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and Metabotropic Glutamate Receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The Metabotropic Glutamate Receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate Phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

GRM3 基因产物(4)

mRNA	Protein	Name
XM_017012073.3	XP_016867562.1	metabotropic glutamate receptor 3 isoform X2
XM_047420268.1	XP_047276224.1	metabotropic glutamate receptor 3 isoform X1
NM_000840.3	NP_000831.2	metabotropic glutamate receptor 3 isoform 1 precursor
NM_001363522.2	NP_001350451.1	metabotropic glutamate receptor 3 isoform 2 precursor

GRM3 蛋白结构

ANF_receptor

NCD3G

7tm_3

0
200
400
600
800
879 a.a.

蛋白主名

其他名称

metabotropic glutamate receptor 3

glutamate receptor, metabotropic 3

GRM3 抗体

目录号	产品名	应用	反应物种
HY-P83232	Metabotropic Glutamate Receptor 3 Antibody (YA2977)	WB	Human, Mouse, Rat
HY-P84578	Metabotropic Glutamate Receptor 3 Antibody (YA4275)	IHC-P, ICC/IF, FC, ELISA	Human

关联疾病

疾病名称

别名

Status Epilepticus

Grand Mal Status Epilepticus	Grand Mal Status
Gcse	Generalized Convulsive Status Epilepticus
Se	Epilepsy With Status Epilepticus

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Huntington Disease

Huntington'S Disease	Huntington Chorea
HD	Huntington'S Chorea
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Schizophreniform Disorder

Schizophreniform Disorders

Psychotic Disorders

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05825	GRM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS05826	Grm3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS05827	Grm3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	GRM3	VGNC	VGNC:29660
Rattus norvegicus	GRM3	RGD	RGD:2744
Macaca mulatta	GRM3	VGNC	VGNC:73287
Mus musculus	GRM3	MGD	MGI:1351340
Canis familiaris	GRM3	VGNC	VGNC:41510
Felis catus	GRM3	VGNC	VGNC:67478

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