2. Gene
  3. Capn1 - calpain 1 Gene

Capn1 - calpain 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 29153 | 基因类型: protein coding

关于 Capn1

功能概要

Enables several functions, including calcium ion binding activity; calcium-dependent cysteine-type endopeptidase activity; and cytoskeletal protein binding activity. Involved in several processes, including negative regulation of NIK/NF-kappaB signaling; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of leukocyte tethering or rolling. Located in cytosol; membrane; and mitochondrion. Biomarker of acute kidney failure; aortic atherosclerosis; epilepsy; and sciatic neuropathy. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1). [provided by Alliance of Genome Resources, Apr 2022]

Capn1 基因产物(1)

mRNA Protein Name
NM_019152.2 NP_062025.1 calpain-1 catalytic subunit
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IMP
IMP: 通过突变表型推断
11893336 RGD
enables calcium-dependent cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
17429681 RGD
enables calcium-dependent cysteine-type endopeptidase activity IMP
IMP: 通过突变表型推断
11893336 RGD
enables cytoskeletal protein binding IDA
IDA: 通过直接分析推断
17429681 RGD
enables enzyme binding IPI
IPI: 通过物理相互作用推断
20850499 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
18559257 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hydrogen peroxide IMP
IMP: 通过突变表型推断
22402252 RGD
involved in negative regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
25653381 RGD
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
21415394 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
22402252 RGD
involved in positive regulation of leukocyte tethering or rolling IMP
IMP: 通过突变表型推断
21415394 RGD
involved in positive regulation of vascular permeability IMP
IMP: 通过突变表型推断
21415394 RGD
involved in protein autoprocessing IDA
IDA: 通过直接分析推断
17182728 RGD
involved in protein catabolic process IDA
IDA: 通过直接分析推断
17429681 RGD
involved in protein catabolic process IMP
IMP: 通过突变表型推断
11893336 RGD
involved in protein catabolic process at postsynapse EXP
EXP: 通过实验结果推断
10825658 RGD
involved in protein catabolic process at postsynapse IDA
IDA: 通过直接分析推断
10825658 RGD
involved in protein catabolic process at postsynapse IEP
IEP: 通过表达模式推断
10825658 RGD
involved in protein catabolic process at postsynapse IMP
IMP: 通过突变表型推断
24285894 RGD
involved in proteolysis IDA
IDA: 通过直接分析推断
22711986 RGD
involved in response to angiotensin IMP
IMP: 通过突变表型推断
21415394 RGD
involved in response to arsenic-containing substance IEP
IEP: 通过表达模式推断
24641850 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
10688895 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
10688895 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
10688895 RGD
is active in postsynapse IMP
IMP: 通过突变表型推断
10688895 RGD
is active in postsynaptic density IDA
IDA: 通过直接分析推断
2843999 RGD
is active in presynapse IDA
IDA: 通过直接分析推断
2843999 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

calpain-1 catalytic subunit

CANP 1

calcium-activated neutral proteinase 1

calpain 1, (mu/I) large subunit

calpain mu-type

calpain-1 large subunit

micromolar-calpain

muCANP

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-158022 CTSL/CAPN1-IN-1 Inhibitor / 否
HY-161342 CTSL/CAPN1-IN-2 Inhibitor / 否
HY-RS01883 CAPN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01895 CAPNS1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17903 Capn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24372 Capn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Capn1 NCBI NCBI:823
Mus musculus Capn1 NCBI NCBI:12333
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