2. Gene
  3. CLCN2 - Clcn2 chloride voltage-gated channel 2 Gene

CLCN2 - Clcn2 chloride voltage-gated channel 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: ClC-2

基因 ID: 29232 | 基因类型: protein coding

关于 CLCN2

功能概要

Enables voltage-gated Chloride Channel activity. Involved in chloride transport and lung development. Located in dendrite and perikaryon. Used to study cystic fibrosis. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 11 and primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2). [provided by Alliance of Genome Resources, Apr 2022]

CLCN2 基因产物(1)

mRNA Protein Name
NM_017137.2 NP_058833.1 chloride channel protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables voltage-gated chloride channel activity IDA
IDA: 通过直接分析推断
1311421 RGD
enables voltage-gated chloride channel activity IMP
IMP: 通过突变表型推断
1334533 RGD
enables voltage-gated monoatomic anion channel activity IDA
IDA: 通过直接分析推断
22405205 RGD
enables volume-sensitive chloride channel activity IMP
IMP: 通过突变表型推断
1334533 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular hypotonic response IMP
IMP: 通过突变表型推断
1334533 RGD
involved in chloride transport IDA
IDA: 通过直接分析推断
1311421 RGD
involved in lung development IMP
IMP: 通过突变表型推断
14711803 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
29344669 RGD
involved in positive regulation of voltage-gated chloride channel activity IMP
IMP: 通过突变表型推断
29344669 RGD
involved in regulation of membrane depolarization during action potential IMP
IMP: 通过突变表型推断
8816717 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in astrocyte end-foot IDA
IDA: 通过直接分析推断
11068136 RGD
located in axon initial segment IDA
IDA: 通过直接分析推断
11068136 RGD
located in dendrite IDA
IDA: 通过直接分析推断
12967985 RGD
located in dendritic spine membrane IDA
IDA: 通过直接分析推断
11068136 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
12967985 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

chloride channel protein 2

chloride channel 2

chloride channel, voltage-sensitive 2

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0680 Lubiprostone (hemiketal) Activator / 否
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02754 CLCN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS22442 Clcn2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS28965 Clcn2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens CLCN2 NCBI NCBI:1181
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