1. Gene
  2. Penk - proenkephalin Gene

Penk - proenkephalin Gene

种属: Rattus norvegicus

同用名: Enk; Penk1; Penk2; Penk-rs

基因 ID: 29237 | 基因类型: protein coding

关于 Penk

功能概要

Predicted to enable Opioid Receptor binding activity. Involved in several processes, including cellular response to organic cyclic compound; general adaptation syndrome, behavioral process; and locomotory exploration behavior. Located in several cellular components, including cell body fiber; perikaryon; and symmetric synapse. Is active in neuronal dense core vesicle lumen and synaptic vesicle lumen. Used to study heroin dependence. Biomarker of Parkinson's disease; alcohol use disorder; dystonia; and spinal disease. Orthologous to human PENK (proenkephalin). [provided by Alliance of Genome Resources, Apr 2022]

Penk 基因产物(1)

mRNA Protein Name
NM_017139.2 NP_058835.2 proenkephalin-A precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to cAMP IEP
IEP: 通过表达模式推断
9826786 RGD
involved in cellular response to oxidative stress IEP
IEP: 通过表达模式推断
11595755 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
8584038 RGD
involved in cellular response to virus IEP
IEP: 通过表达模式推断
8411369 RGD
involved in cellular response to vitamin D IEP
IEP: 通过表达模式推断
8584038 RGD
involved in general adaptation syndrome, behavioral process IEP
IEP: 通过表达模式推断
23665402 RGD
involved in glial cell proliferation IEP
IEP: 通过表达模式推断
9221949 RGD
involved in locomotory exploration behavior IMP
IMP: 通过突变表型推断
23368426 RGD
involved in osteoblast differentiation IEP
IEP: 通过表达模式推断
8584038 RGD
involved in positive regulation of behavioral fear response IMP
IMP: 通过突变表型推断
23368426 RGD
involved in response to calcium ion IEP
IEP: 通过表达模式推断
10426412 RGD
involved in response to epinephrine IEP
IEP: 通过表达模式推断
8784263 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
12503826 RGD
involved in response to ethanol IDA
IDA: 通过直接分析推断
9581644 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
20184566 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
22200548 RGD
involved in response to immobilization stress IEP
IEP: 通过表达模式推断
15300902 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
8784263 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
25086310 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
23410195 RGD
involved in synaptic signaling via neuropeptide EXP
EXP: 通过实验结果推断
355888 RGD
involved in synaptic signaling via neuropeptide IMP
IMP: 通过突变表型推断
355888 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
23912034 RGD
located in axon terminus IDA
IDA: 通过直接分析推断
20686827 RGD
located in cell body fiber IDA
IDA: 通过直接分析推断
20686827 RGD
located in dendrite IDA
IDA: 通过直接分析推断
20686827 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
2695900 RGD
is active in neuronal dense core vesicle lumen IDA
IDA: 通过直接分析推断
8847409 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
23912034 RGD
located in symmetric synapse IDA
IDA: 通过直接分析推断
20686827 RGD
is active in synaptic vesicle lumen IDA
IDA: 通过直接分析推断
8847409 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

proenkephalin-A

enkephalin

preproenkephalin 2

proenkephalin 1

proenkephalin 2

proenkephalin related sequence

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Penk NCBI NCBI:5179