2. Gene
  3. Drd3 - dopamine receptor D3 Gene

Drd3 - dopamine receptor D3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：多巴胺受体 D3

种属: Rattus norvegicus

基因 ID: 29238 | 基因类型: protein coding

关于 Drd3

Primary_assembly 11: 56,879,689-56,940,596 reverse strand.mRatBN7.2:CM026984.1

This gene has 2 transcripts (splice variants), 206 orthologues, 35 paralogues and is associated with 27 phenotypes. Restricted expression toward (RPKM 1.9).

功能概要

该基因编码的蛋白可启动 D1 多巴胺受体结合活性；多巴胺神经递质受体活性，通过 Gi/Go 耦合；和蛋白质结构域特异性结合活性。参与多个过程，包括腺苷酸环化酶抑制多巴胺受体信号通路；分泌调节； RNA 聚合酶 II 对转录的调控。位于多个细胞成分中，包括细胞的顶端部分；内吞囊泡；和质膜。在 GABA 能突触和谷氨酸能突触中活跃。是突触后密度膜的组成部分。用于研究帕金森症；遗忘症;特发性震颤;和高血压。海洛因依赖和视觉癫痫的生物标志物。该基因的人类直系同源物与帕金森病有关；特发性震颤;原发性震颤 1；和精神分裂症。与人类 DRD3（多巴胺受体 D3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables D1 Dopamine Receptor binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and protein domain specific binding activity. Involved in several processes, including adenylate cyclase-inhibiting Dopamine Receptor signaling pathway; regulation of secretion; and regulation of transcription by RNA polymerase II. Located in several cellular components, including apical part of cell; endocytic vesicle; and plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic density membrane. Used to study Parkinsonism; amnestic disorder; essential tremor; and hypertension. Biomarker of heroin dependence and visual epilepsy. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (Dopamine Receptor D3). [provided by Alliance of Genome Resources, Apr 2022]

Drd3 基因产物(1)

mRNA Protein Name
NM_017140.2 NP_058836.1 D(3) dopamine receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D1 dopamine receptor binding IPI
IPI: 通过物理相互作用推断
14732731 RGD
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
IDA: 通过直接分析推断
1975644 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
14499480 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
14617818 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor internalization IDA
IDA: 通过直接分析推断
14617818 RGD
involved in G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
15265811 RGD
involved in acid secretion IDA
IDA: 通过直接分析推断
8302280 RGD
involved in adenylate cyclase-inhibiting dopamine receptor signaling pathway IDA
IDA: 通过直接分析推断
8302280 RGD
involved in autophagy IMP
IMP: 通过突变表型推断
26649942 RGD
involved in behavioral response to cocaine IMP
IMP: 通过突变表型推断
16026479 RGD
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
25989500 RGD
involved in negative regulation of sodium:proton antiporter activity IMP
IMP: 通过突变表型推断
15265811 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16902178 RGD
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15584906 RGD
involved in positive regulation of mitotic nuclear division IMP
IMP: 通过突变表型推断
8302280 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16902178 RGD
involved in regulation of circadian sleep/wake cycle, sleep IMP
IMP: 通过突变表型推断
15913875 RGD
involved in regulation of dopamine secretion IMP
IMP: 通过突变表型推断
16490190 RGD
involved in regulation of locomotion involved in locomotory behavior IMP
IMP: 通过突变表型推断
22394078 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization EXP
EXP: 通过实验结果推断
16510729 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: 通过直接分析推断
16510729 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: 通过表达模式推断
16510729 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
1975644 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse EXP
EXP: 通过实验结果推断
16510729 RGD
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
16510729 RGD
located in apical part of cell IDA
IDA: 通过直接分析推断
9822449 RGD
located in cell projection IDA
IDA: 通过直接分析推断
15584906 RGD
located in endocytic vesicle IDA
IDA: 通过直接分析推断
14617818 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
23001156 RGD
located in membrane IDA
IDA: 通过直接分析推断
8302280 RGD
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
23001156 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Drd3 蛋白结构

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (29 - 439)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (30 - 56)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (63 - 86)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (102 - 132)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (149 - 167)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (184 - 209)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (367 - 397)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (407 - 432)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 446 a.a.
蛋白主名 其他名称

D(3) dopamine receptor

dopaminergic receptor D3

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-19654 GSK598809 Antagonist 99.74% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19654C (-)-GSK598809 hydrochloride Antagonist 99.64% 否
HY-RS04000 DRD3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS04001 Drd3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS04002 Drd3 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-19654B (-)-GSK598809 Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Drd3 NCBI NCBI:1814
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