2. Gene
  3. Epas1 - endothelial PAS domain protein 1 Gene

Epas1 - endothelial PAS domain protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: HLF; Hif2a; HIF2 alpha; HIF-2 alpha

基因 ID: 29452 | 基因类型: protein coding

关于 Epas1

功能概要

Enables DNA-binding transcription factor activity and cobalt ion binding activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including norepinephrine biosynthetic process; positive regulation of lung alveolus development; and regulation of cellular biosynthetic process. Located in cytoplasm and nucleus. Used to study acute kidney failure and intermittent claudication. Biomarker of artery disease (multiple); glucose metabolism disease (multiple); polycystic kidney disease; and renal cell carcinoma. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Epas1 基因产物(1)

mRNA Protein Name
NM_023090.2 NP_075578.2 endothelial PAS domain-containing protein 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
11237857 RGD
enables cobalt ion binding IDA
IDA: 通过直接分析推断
11688986 RGD
contributes to sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12675925 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
12099714 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
12099714 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
12099714 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20496369 RGD
involved in norepinephrine biosynthetic process IMP
IMP: 通过突变表型推断
19457096 RGD
involved in positive regulation of dopamine biosynthetic process IMP
IMP: 通过突变表型推断
19457096 RGD
involved in positive regulation of lung alveolus development IEP
IEP: 通过表达模式推断
23962064 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11237857 RGD
involved in response to hypoxia IDA
IDA: 通过直接分析推断
12675925 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

endothelial PAS domain-containing protein 1

EPAS-1

HIF-2-alpha

HIF2-alpha

hypoxia inducible factor 2, alpha subunit

hypoxia inducible factor 2a

hypoxia-inducible factor 2-alpha

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04409 EPAS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-B0660S1 Eicosapentaenoic acid 1,2,3,4,5-13C5 Activator / 否
HY-RS18998 Epas1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS25487 Epas1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Epas1 NCBI NCBI:2034
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