2. Gene
  3. Ddit3 - DNA-damage inducible transcript 3 Gene

Ddit3 - DNA-damage inducible transcript 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: RM4; CHOP; Chop10; CHOP-10; Gadd153

基因 ID: 29467 | 基因类型: protein coding

关于 Ddit3

功能概要

Enables DNA-binding transcription factor activity and protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including cellular response to manganese ion; positive regulation of Autophagy in response to ER overload; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of CHOP-C/EBP complex. Biomarker of several diseases, including borna disease; brain ischemia; chronic obstructive pulmonary disease; pulmonary venoocclusive disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3). [provided by Alliance of Genome Resources, Apr 2022]

Ddit3 基因产物(2)

mRNA Protein Name
NM_001109986.1 NP_001103456.1 DNA damage-inducible transcript 3 protein
NM_024134.2 NP_077048.2 DNA damage-inducible transcript 3 protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to DNA binding IDA
IDA: 通过直接分析推断
8657121 RGD
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
15829559 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8657121 RGD
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
8657121 RGD
contributes to sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8657121 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ER overload response IMP
IMP: 通过突变表型推断
11158311 RGD
involved in cellular response to manganese ion IEP
IEP: 通过表达模式推断
23934647 RGD
involved in embryonic organ development IEP
IEP: 通过表达模式推断
10419986 RGD
involved in luteolysis IEP
IEP: 通过表达模式推断
25332219 RGD
involved in negative regulation of CREB transcription factor activity IDA
IDA: 通过直接分析推断
15829559 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8657121 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15829559 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
15826945 RGD
involved in positive regulation of autophagy in response to ER overload IMP
IMP: 通过突变表型推断
25772147 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
28694771 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8657121 RGD
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11158311 RGD
involved in regulation of autophagy IMP
IMP: 通过突变表型推断
28694771 RGD
involved in response to amphetamine IEP
IEP: 通过表达模式推断
17105900 RGD
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
8657121 RGD
involved in response to hydrogen peroxide IEP
IEP: 通过表达模式推断
12609979 RGD
involved in response to kainic acid IEP
IEP: 通过表达模式推断
17251432 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
12609979 RGD
involved in response to oxidative stress IEP
IEP: 通过表达模式推断
11811998 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
20026213 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
15921666 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CHOP-C/EBP complex IPI
IPI: 通过物理相互作用推断
8657121 RGD
located in nucleus IDA
IDA: 通过直接分析推断
8657121 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DNA damage-inducible transcript 3 protein

C/EBP homologous protein

C/EBP zeta

CCAAT/enhancer-binding protein homologous protein

DDIT-3

c/EBP-homologous protein 10

growth arrest and DNA-damage-inducible protein GADD153

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03614 DDIT3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18059 Ddit3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24534 Ddit3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ddit3 NCBI NCBI:1649
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