2. Gene
  3. Usp8 - ubiquitin specific peptidase 8 Gene

Usp8 - ubiquitin specific peptidase 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 296121 | 基因类型: protein coding

关于 Usp8

功能概要

Predicted to enable thiol-dependent Deubiquitinase. Involved in cellular response to dexamethasone stimulus; cellular response to nerve growth factor stimulus; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Located in cytosol and dendritic spine. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with early endosome. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Apr 2022]

Usp8 基因产物(1)

mRNA Protein Name
NM_001106502.1 NP_001099972.1 ubiquitin carboxyl-terminal hydrolase 8
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
19527720 RGD
involved in cellular response to nerve growth factor stimulus IDA
IDA: 通过直接分析推断
25662281 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IDA
IDA: 通过直接分析推断
25505317 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IEP
IEP: 通过表达模式推断
25505317 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IMP
IMP: 通过突变表型推断
25505317 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome IDA
IDA: 通过直接分析推断
25662281 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
25505317 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
25505317 RGD
is active in postsynaptic density IDA
IDA: 通过直接分析推断
25505317 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 8

ubiquitin specific protease 8

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-151563A OTUB1/USP8-IN-1 TFA Inhibitor 99.56% 否
HY-162312 LLK203 Inhibitor 98.58% 否
HY-149902 USP8-IN-3 Inhibitor 99.17% 否
HY-149901 USP8-IN-2 Inhibitor 99.91% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Usp8 NCBI NCBI:9101
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