1. Gene
  2. DPP7 - dipeptidyl peptidase 7 Gene

DPP7 - dipeptidyl peptidase 7 Gene

中文名称:二肽基肽酶 7

种属: Homo sapiens

同用名: QPP; DPP2; DPPII

基因 ID: 29952 | 基因类型: protein coding

关于 DPP7

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,110,546-137,118,306 (from NCBI)

This gene has 13 transcripts (splice variants), 191 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 29.2), testis (RPKM 27.1) and 25 other tissues.

功能概要

该基因编码的蛋白质是在静止淋巴细胞中表达的脯氨酸后裂解氨肽酶。静息淋巴细胞通过抑制细胞凋亡来维持,这种状态会被这种新型丝氨酸蛋白酶的抑制所破坏。该酶与脯氨酰羧肽酶具有很强的序列同源性,在酸性和中性 pH 值下均有活性。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a post-proline cleaving Aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of Apoptosis, a state which is disrupted by inhibition of this novel serine protease. The Enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]

DPP7 基因产物(1)

mRNA Protein Name
NM_013379.3 NP_037511.2 dipeptidyl peptidase 2 preproprotein

DPP7 蛋白结构

Peptidase_S28

Peptidase_S28: Serine carboxypeptidase S28 (38 - 464)

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  • 492 a.a.
蛋白主名 其他名称

dipeptidyl peptidase 2

DPP II

重组 DPP7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75280 DPP2 Protein, Human (HEK293, His) Q9UHL4 (G22-L492) ≥95%

关联疾病

疾病名称 别名
Periodontitis, Chronic

Chronic Periodontitis

Periodontitis, Adult

Complement Component 7 Deficiency

C7 Deficiency

C7D

Facial Hemiatrophy

Parry-Romberg Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus DPP7 VGNC VGNC:82328
Rattus norvegicus DPP7 RGD RGD:71073
Canis familiaris DPP7 VGNC VGNC:40076
Bos taurus DPP7 VGNC VGNC:28188
Mus musculus DPP7 MGD MGI:1933213
Macaca mulatta DPP7 VGNC VGNC:103257
Others DPP7 NCBI