2. Gene
  3. Map4k4 - mitogen-activated protein kinase kinase kinase kinase 4 Gene

Map4k4 - mitogen-activated protein kinase kinase kinase kinase 4 Gene

  • 基因
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶激酶激酶激酶 4

种属: Rattus norvegicus

基因 ID: 301363 | 基因类型: protein coding

关于 Map4k4

Primary_assembly 9: 42,200,278-42,326,698 forward strand.mRatBN7.2:CM026982.1

This gene has 8 transcripts (splice variants), 281 orthologues, 36 paralogues and is associated with 7 phenotypes.

功能概要

预测该基因编码的蛋白可启动 ATP 绑定活动；激酶活性；和微管结合活性。参与胰岛素分泌的负调节，参与细胞对葡萄糖刺激的反应和神经元投射再生的负调节。预测位于粘着斑。预计在细胞质中有活性。与人 MAP4K4（丝裂原活化蛋白激酶激酶 kinase kinase 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ATP binding activity; kinase activity; and microtubule binding activity. Involved in negative regulation of Insulin secretion involved in cellular response to glucose stimulus and negative regulation of neuron projection regeneration. Predicted to be located in focal adhesion. Predicted to be active in cytoplasm. Orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Map4k4 基因产物(2)

mRNA Protein Name
NM_001401996.1 NP_001388925.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 2
NM_001106904.2 NP_001100374.2 mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

相关产品

Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100343 GNE-495 Inhibitor 99.40% 否
HY-111754 DMX-5804 Inhibitor 99.83% 否
HY-19562 PF-06260933 Inhibitor 99.67% 否
HY-125012 MAP4K4-IN-3 Inhibitor 99.15% 否
HY-132290 TGFβRI-IN-3 Inhibitor 98.04% 否
HY-U00428A GNE 220 hydrochloride Inhibitor 98.22% 否
HY-U00428 GNE 220 Inhibitor / 否
HY-156523 TNIK&MAP4K4-IN-1 / 否
HY-RS08080 MAP4K4 Human Pre-designed siRNA Set A / 否
HY-RS08081 Map4k4 Mouse Pre-designed siRNA Set A / 否
HY-RS08082 Map4k4 Rat Pre-designed siRNA Set A / 否
HY-160623 TNIK&MAP4K4-IN-2 Inhibitor / 否
HY-19562A PF-06260933 hydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Map4k4 NCBI NCBI:9448
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