2. Gene
  3. Vcl - vinculin Gene

Vcl - vinculin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 305679 | 基因类型: protein coding

关于 Vcl

功能概要

Enables small GTPase binding activity. Predicted to be involved in several processes, including cell-cell junction assembly; platelet aggregation; and protein localization to cell surface. Predicted to act upstream of or within cell adhesion; plasma membrane bounded cell projection organization; and regulation of cell migration. Located in Z disc; intercalated disc; and sarcolemma. Colocalizes with actin filament; focal adhesion; and stress fiber. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin). [provided by Alliance of Genome Resources, Apr 2022]

Vcl 基因产物(1)

mRNA Protein Name
NM_001107248.1 NP_001100718.1 vinculin
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
15506980 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Z disc IDA
IDA: 通过直接分析推断
1514597 RGD
located in actin filament IDA
IDA: 通过直接分析推断
15506980 RGD
located in focal adhesion IDA
IDA: 通过直接分析推断
15506980 RGD
located in intercalated disc IDA
IDA: 通过直接分析推断
1514597 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
1514597 RGD
located in stress fiber IDA
IDA: 通过直接分析推断
15506980 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

vinculin

metavinculin

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15620 VCL Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19870 Vcl Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26369 Vcl Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Vcl NCBI NCBI:7414
Mus musculus Vcl NCBI NCBI:22330
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