2. Gene
  3. Akr1c1 - aldo-keto reductase family 1, member C1 Gene

Akr1c1 - aldo-keto reductase family 1, member C1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Akr1c6; Hsd17b5

基因 ID: 307092 | 基因类型: protein coding

关于 Akr1c1

功能概要

Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and testosterone 17-beta-dehydrogenase (NADP+) activity. Involved in response to estrogen and response to xenobiotic stimulus. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Apr 2022]

Akr1c1 基因产物(1)

mRNA Protein Name
NM_001033697.1 NP_001028869.1 aldo-keto reductase family 1, member C1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity IDA
IDA: 通过直接分析推断
16788056 RGD
enables testosterone 17-beta-dehydrogenase (NADP+) activity IDA
IDA: 通过直接分析推断
16788056 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to estrogen IDA
IDA: 通过直接分析推断
16788056 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
16788056 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18574251 RGD
located in nucleus IDA
IDA: 通过直接分析推断
18574251 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

aldo-keto reductase family 1, member C1

20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1

aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1

20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

aldo-keto reduc

相关产品

Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0376 Liquiritin 99.99% 否
HY-150644 S07-2010 Inhibitor 98.35% 否
HY-114009 AKR1C1-IN-1 Inhibitor 99.38% 否
HY-D1341 Coumberone 99.95% 否
HY-118819 5-Bromo-3-phenyl salicylic acid Inhibitor 98.00% 否
HY-113850 CPSA Inhibitor / 否
HY-131586 3,7-Dihydroxyflavone / 否
HY-163609 PROTAC AKR1C3 degrader-1 Degrader / 否
HY-172598 Keap1-Nrf2-IN-28 Inhibitor / 否
HY-173132 AKR1Cs-IN-1 Inhibitor / 否
HY-N0376R Liquiritin (Standard) / 否
HY-RS00534 AKR1C1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23471 Akr1c1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Akr1c1 NCBI NCBI:1645
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