EHD2 - EH domain containing 2 Gene

中文名称：含 EH 结构域 2

种属: Homo sapiens

同用名: PAST2

关于 EHD2

功能概要

该基因编码包含 EH 结构域的蛋白质家族的成员。这些蛋白质的特征在于 C 端 EF 手结构域、N 端的核苷酸结合共有位点和二分核定位信号。编码的蛋白质通过 N 末端结构域与肌动蛋白细胞骨架相互作用，并通过 C 末端 EH 结构域与 EH 结构域结合蛋白结合。这种相互作用似乎将网格蛋白依赖性内吞作用与肌动蛋白联系起来，表明该基因产物参与了内吞途径。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin Cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008]