1. Gene
  2. Nnt - nicotinamide nucleotide transhydrogenase Gene

Nnt - nicotinamide nucleotide transhydrogenase Gene

种属: Rattus norvegicus

基因 ID: 310378 | 基因类型: protein coding

关于 Nnt

功能概要

Predicted to enable NAD binding activity; NAD(P)+ transhydrogenase activity; and NADP binding activity. Involved in several processes, including cell redox homeostasis; oxygen homeostasis; and positive regulation of hydrogen peroxide catabolic process. Located in mitochondrion. Biomarker of obesity. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Nnt 基因产物(1)

mRNA Protein Name
NM_001013157.1 NP_001013175.1 NAD(P) transhydrogenase, mitochondrial
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in NADPH regeneration IMP
IMP: 通过突变表型推断
22198343 RGD
involved in cell redox homeostasis IMP
IMP: 通过突变表型推断
22198343 RGD
involved in cellular oxidant detoxification IMP
IMP: 通过突变表型推断
22198343 RGD
involved in intracellular oxygen homeostasis IMP
IMP: 通过突变表型推断
24722990 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
22198343 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
22198343 RGD
involved in positive regulation of hydrogen peroxide catabolic process IMP
IMP: 通过突变表型推断
24722990 RGD
involved in positive regulation of mitochondrial membrane potential IMP
IMP: 通过突变表型推断
24722990 RGD
involved in response to vitamin IEP
IEP: 通过表达模式推断
25761734 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

NAD(P) transhydrogenase, mitochondrial

Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase)

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nnt NCBI NCBI:23530
Mus musculus Nnt NCBI NCBI:18115