HLA-DPA1 - major histocompatibility complex, class II, DP alpha 1 Gene

中文名称：主要组织相容性复合体，II 类，DP α 1

种属: Homo sapiens

同用名: DPA1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DPA; HLA-DP1A; HLA-DPB1

基因 ID: 3113 | 基因类型: protein coding

关于 HLA-DPA1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,064,569-33,080,748 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 67 orthologues, 13 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 361.8), spleen (RPKM 361.5) and 24 other tissues.

功能概要

HLA-DPA1 属于 HLA II 类α链旁系同源物。这种 II 类分子是一种异二聚体，由一条 alpha (DPA) 和一条 beta (DPB) 链组成，它们都锚定在膜中。它通过呈递源自细胞外蛋白的肽在免疫系统中发挥核心作用。 II 类分子在抗原呈递细胞 (APC：B 淋巴细胞、树突细胞、巨噬细胞) 中表达。 α 链约为 33-35 kDa，其基因包含 5 个外显子。外显子 1 编码前导肽，外显子 2 和 3 编码两个细胞外结构域，外显子 4 编码跨膜结构域和细胞质尾部。在 DP 分子中，α 链和 β 链均包含指定肽结合特异性的多态性，从而产生多达 4 种不同的分子。[RefSeq 提供，2008 年 7 月]

HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

HLA-DPA1 基因产物(4)

mRNA	Protein	Name
NM_001242524.2	NP_001229453.1	HLA class II histocompatibility antigen, DP alpha 1 chain precursor
NM_001242525.2	NP_001229454.1	HLA class II histocompatibility antigen, DP alpha 1 chain precursor
NM_001405020.1	NP_001391949.1	HLA class II histocompatibility antigen, DP alpha 1 chain precursor
NM_033554.4	NP_291032.2	HLA class II histocompatibility antigen, DP alpha 1 chain precursor

蛋白主名

其他名称

HLA class II histocompatibility antigen, DP alpha 1 chain

HLA DPA1

重组 HLA-DPA1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71697	HLA-DPA1 Protein, Human (His)	P20036 (A29-E222)	≥95%

HLA-DPA1 抗体

目录号	产品名	应用	反应物种
HY-P81436	HLA-DP Antibody (YA1181)	IHC-P	Human
HY-P84161	HLA-DPA1 Antibody (YA3858)	WB, IHC-P, FC, ELISA	Human
HY-P84162	HLA-DPA1 Antibody (YA3859)	IHC-P, FC, ELISA	Human, Rat

关联疾病

疾病名称

别名

Berylliosis

Beryllium Poisoning	Beryllium Disease
Lung Fibrosis With Berylliosis

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Rubella

German Measles	Three Day Measles
Rubella Nos

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06203	HLA-DPA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	HLA-DPA1	RGD	RGD:1595921

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HLA-DPA1 - major histocompatibility complex, class II, DP alpha 1 Gene

关于 HLA-DPA1

功能概要

HLA-DPA1 基因产物(4)

重组 HLA-DPA1 蛋白

HLA-DPA1 抗体

关联疾病

直系同源

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HLA-DPA1 - major histocompatibility complex, class II, DP alpha 1 Gene

关于 HLA-DPA1

功能概要

HLA-DPA1 基因产物(4)

重组 HLA-DPA1 蛋白

HLA-DPA1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z