2. Gene
  3. Kmt2a - lysine methyltransferase 2A Gene

Kmt2a - lysine methyltransferase 2A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Mll; Mll1

基因 ID: 315606 | 基因类型: protein coding

关于 Kmt2a

功能概要

Predicted to enable several functions, including lysine-acetylated histone binding activity; protein homodimerization activity; and protein methyltransferase activity. Involved in membrane depolarization and response to potassium ion. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of MLL1 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Kmt2a 基因产物(5)

mRNA Protein Name
XM_039082347.1 XP_038938275.1 histone-lysine N-methyltransferase 2A isoform X3
XM_039082346.1 XP_038938274.1 histone-lysine N-methyltransferase 2A isoform X2
XM_039082348.1 XP_038938276.1 histone-lysine N-methyltransferase 2A isoform X5
XM_008766179.2 XP_008764401.2 histone-lysine N-methyltransferase 2A isoform X4
XM_039082345.1 XP_038938273.1 histone-lysine N-methyltransferase 2A isoform X1
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to transforming growth factor beta stimulus IMP
IMP: 通过突变表型推断
31570196 RGD
involved in membrane depolarization IEP
IEP: 通过表达模式推断
20211609 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
31570196 RGD
involved in protein modification process IMP
IMP: 通过突变表型推断
34694864 RGD
involved in response to potassium ion IEP
IEP: 通过表达模式推断
20211609 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

histone-lysine N-methyltransferase MLL

histone-lysine N-methyltransferase 2A

Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or trithorax Drosophila gene)

Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)

lysine (K)-specific methyltransferase 2A

myeloid/lymphoid or mixed-lineage le

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-148669A Bleximenib oxalate 98.0% Phase 2
HY-148669 Bleximenib 99.36% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148669B (S)-Bleximenib oxalate Control 98.37% 否
HY-170832 Menin–KMT2A-IN-1 Inhibitor / 否
HY-RS07401 KMT2A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18528 Kmt2a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25010 Kmt2a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kmt2a NCBI NCBI:4297
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