2. Gene
  3. HMGCS1 - 3-hydroxy-3-methylglutaryl-CoA synthase 1 Gene

HMGCS1 - 3-hydroxy-3-methylglutaryl-CoA synthase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：3-羟基-3-甲基戊二酰辅酶 A 合酶 1

种属: Homo sapiens

同用名: HMGCS

基因 ID: 3157 | 基因类型: protein coding

关于 HMGCS1

Cytogenetic location: 5p12 Genomic coordinates (GRCh38): 5:43,287,470-43,313,412 (from NCBI)

This gene has 7 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 48.5), liver (RPKM 37.3) and 23 other tissues.

功能概要

启用蛋白质同源二聚化活性。预计参与乙酰辅酶 A 代谢过程和法尼基二磷酸生物合成过程，甲羟戊酸途径。预计位于细胞质中。预计在胞质溶胶中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein homodimerization activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

HMGCS1 基因产物(9)

mRNA Protein Name
NM_001098272.3 NP_001091742.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_001324219.2 NP_001311148.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_001324220.2 NP_001311149.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_001324222.2 NP_001311151.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2
NM_001324223.2 NP_001311152.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2
NM_001324224.2 NP_001311153.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2
NM_001330663.2 NP_001317592.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_001364188.2 NP_001351117.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_002130.8 NP_002121.4 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
20346956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HMGCS1 蛋白结构

HMG_CoA_synt_N

HMG_CoA_synt_N: Hydroxymethylglutaryl-coenzyme A synthase N terminal (13 - 186)

HMG_CoA_synt_C

HMG_CoA_synt_C: Hydroxymethylglutaryl-coenzyme A synthase C terminal (187 - 469)

  • 0
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  • 520 a.a.
蛋白主名 其他名称

hydroxymethylglutaryl-CoA synthase, cytoplasmic

3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06241 HMGCS1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18093 Hmgcs1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24568 Hmgcs1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24905 Hmgcs2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus HMGCS1 VGNC VGNC:67597
Canis familiaris HMGCS1 VGNC VGNC:103681
Bos taurus HMGCS1 VGNC VGNC:29880
Rattus norvegicus HMGCS1 RGD RGD:70970
Macaca mulatta HMGCS1 VGNC VGNC:73485
Mus musculus HMGCS1 MGD MGI:107592
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