2. Gene
  3. Gpr183 - G protein-coupled receptor 183 Gene

Gpr183 - G protein-coupled receptor 183 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 183

种属: Mus musculus

同用名: Ebi2

基因 ID: 321019 | 基因类型: protein coding

关于 Gpr183

Chromosome 14: 122,189,963-122,202,607 reverse strand.GRCm39:CM001007.3

This gene has 2 transcripts (splice variants), 207 orthologues, 5 paralogues and is associated with 12 phenotypes. Broad expression in spleen adult (RPKM 9.1), mammary gland adult (RPKM 4.9) and 15 other tissues.

功能概要

该基因编码的蛋白可启动氧甾醇结合活性。参与多个过程，包括树突状细胞稳态；白细胞趋化性；和白细胞分化。作用于白细胞趋化性的上游或内部。预测位于质膜中。以多种结构表达，包括 Peyer's patch；中枢神经系统;泌尿生殖系统；免疫系统;和肠道。与人类 GPR183（G 蛋白偶联受体 183）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables oxysterol binding activity. Involved in several processes, including dendritic cell homeostasis; leukocyte chemotaxis; and leukocyte differentiation. Acts upstream of or within leukocyte chemotaxis. Predicted to be located in plasma membrane. Is expressed in several structures, including Peyer's patch; central nervous system; genitourinary system; immune system; and intestine. Orthologous to human GPR183 (G protein-coupled receptor 183). [provided by Alliance of Genome Resources, Apr 2022]

Gpr183 基因产物(1)

mRNA Protein Name
NM_183031.2 NP_898852.2 G-protein coupled receptor 183
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables oxysterol binding IDA
IDA: 通过直接分析推断
21796211 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell chemotaxis IMP
IMP: 通过突变表型推断
27147029 MGI
involved in T follicular helper cell differentiation IMP
IMP: 通过突变表型推断
27147029 MGI
involved in adaptive immune response IMP
IMP: 通过突变表型推断
23502855 MGI
involved in cell chemotaxis IMP
IMP: 通过突变表型推断
26438360 MGI
involved in dendritic cell chemotaxis IMP
IMP: 通过突变表型推断
23502855 MGI
involved in dendritic cell homeostasis IMP
IMP: 通过突变表型推断
23502855 MGI
involved in humoral immune response IMP
IMP: 通过突变表型推断
19597478 MGI
acts upstream of or within leukocyte chemotaxis IDA
IDA: 通过直接分析推断
25348153 MGI
involved in mature B cell differentiation involved in immune response IMP
IMP: 通过突变表型推断
19597478 MGI
involved in osteoclast differentiation IMP
IMP: 通过突变表型推断
26438360 MGI
involved in positive regulation of B cell proliferation IDA
IDA: 通过直接分析推断
21673108 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Gpr183 蛋白结构

7tmA_EBI2

7tmA_EBI2: cd15159 (27 - 314)

7tmA_EBI2

7tmA_EBI2: cd15159 (27 - 54)

7tmA_EBI2

7tmA_EBI2: cd15159 (61 - 86)

7tmA_EBI2

7tmA_EBI2: cd15159 (99 - 129)

7tmA_EBI2

7tmA_EBI2: cd15159 (141 - 163)

7tmA_EBI2

7tmA_EBI2: cd15159 (188 - 217)

7tmA_EBI2

7tmA_EBI2: cd15159 (232 - 262)

7tmA_EBI2

7tmA_EBI2: cd15159 (282 - 307)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
蛋白主名 其他名称

G-protein coupled receptor 183

EBV-induced G-protein coupled receptor 2 homolog

Epstein-Barr virus induced gene 2

epstein-Barr virus-induced G-protein coupled receptor 2 homolog

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-175306 GPR183 inverse agonist-1 Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-113962 7α,25-Dihydroxycholesterol Agonist 99.88% 否
HY-162011 GPR183 antagonist-2 Antagonist 99.96% 否
HY-147222 SAE-14 Antagonist 98.60% 否
HY-162618 PSB-KK1445 Agonist 99.47% 否
HY-163796 GPR183-IN-2 Inhibitor 99.90% 否
HY-113962S 7α,25-Dihydroxycholesterol-d6 / 否
HY-157939 GPR183 antagonist-3 Antagonist 98.79% 否
HY-163795 GPR183-IN-1 Inhibitor / 否
HY-RS05690 GPR183 Human Pre-designed siRNA Set A / 否
HY-RS05691 Gpr183 Mouse Pre-designed siRNA Set A / 否
HY-RS05692 Gpr183 Rat Pre-designed siRNA Set A / 否
HY-400897 7α,25-Dihydroxycholesterol intermediate-1 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gpr183 NCBI NCBI:1880
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