HOXB4 - homeobox B4 Gene

中文名称：同源框 B4

种属: Homo sapiens

同用名: HOX2; HOX2F; HOX-2.6

关于 HOXB4

功能概要

该基因是 Antp 同源框家族的成员，编码具有同源框 DNA 结合域的核蛋白。它包含在位于 17 号染色体上的同源框 B 基因簇中。编码的蛋白质作为参与发育的序列特异性转录因子发挥作用。这种蛋白质的细胞内或异位表达可在体内和体外扩增造血干细胞和祖细胞，使其成为治疗性干细胞扩增的潜在候选者。[RefSeq 提供，2008 年 7 月]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]