2. Gene
  3. HSF4 - heat shock transcription factor 4 Gene

HSF4 - heat shock transcription factor 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：热休克转录因子 4

种属: Homo sapiens

同用名: CTM; CTRCT5

基因 ID: 3299 | 基因类型: protein coding

关于 HSF4

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,163,761-67,169,941 (from NCBI)

This gene has 29 transcripts (splice variants), 217 orthologues, 9 paralogues and is associated with 5 phenotypes. Ubiquitous expression in prostate (RPKM 12.6), skin (RPKM 8.5) and 24 other tissues.

功能概要

热休克转录因子 (HSF) 在热或其他应激条件下激活热休克反应基因。 HSF4 缺乏所有脊椎动物 HSF 共有的羧基末端疏水重复序列，并被认为参与了 DNA 结合活性的负调节。已经描述了编码不同同种型并具有不同转录活性的两种可变剪接转录本。[RefSeq 提供，2008 年 7 月]

Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or Other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]

HSF4 基因产物(4)

mRNA Protein Name
NM_001040667.3 NP_001035757.1 heat shock factor protein 4 isoform b
NM_001374674.1 NP_001361603.1 heat shock factor protein 4 isoform a
NM_001374675.1 NP_001361604.1 heat shock factor protein 4 isoform b
NM_001538.4 NP_001529.2 heat shock factor protein 4 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
8972228 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8972228 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
16581800 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8972228 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
8972228 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HSF4 蛋白结构

HSF_DNA-bind

HSF_DNA-bind: HSF-type DNA-binding (19 - 121)

  • 0
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  • 492 a.a.
蛋白主名 其他名称

heat shock factor protein 4

HSF 4

关联疾病

疾病名称 别名
Cataract 5, Multiple Types

CTRCT5

Cataract, Marner Type

Cataract 5 Multiple Types

Cam

Cataract, Lamellar

Cataract Marner Type

Ctm

Cataract, Type 5, Multiple Types
Early-Onset Lamellar Cataract
Cataract 44

CTRCT44

Total Early-Onset Cataract

Cataract 44 And Hypotrichosis

Cataract And Hypotrichosis

Cataract, Type 44
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Anterior Spinal Artery Syndrome

Anterior Spinal Artery Occlusion Syndrome
Posterior Polar Cataract

Cataract, Posterior Polar
Nance-Horan Syndrome

NHS

Cataract-Dental Syndrome

Cataract, X-Linked, With Hutchinsonian Teeth

Mesiodens-Cataract Syndrome

Cataract X-Linked With Hutchinsonian Teeth

Cataract Dental Syndrome

Mesiodens Cataract Syndrome
Senile Cataract
Amblyopia

Lazy Eye
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06411 HSF4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20289 Hsf4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26797 Hsf4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus HSF4 VGNC VGNC:67663
Mus musculus HSF4 MGD MGI:1347058
Rattus norvegicus HSF4 RGD RGD:1310808
Macaca mulatta HSF4 VGNC VGNC:73533
Bos taurus HSF4 VGNC VGNC:29984
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