2. Gene
  3. HTR4 - 5-hydroxytryptamine receptor 4 Gene

HTR4 - 5-hydroxytryptamine receptor 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：5-羟色胺受体 4

种属: Homo sapiens

同用名: 5-HT4; 5-HT4R

基因 ID: 3360 | 基因类型: protein coding

关于 HTR4

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:148,451,032-148,654,527 (from NCBI)

This gene has 13 transcripts (splice variants), 201 orthologues and 25 paralogues. Biased expression in small intestine (RPKM 2.1), duodenum (RPKM 1.1) and 5 other tissues.

功能概要

该基因是血清素受体家族的成员，血清素受体是 G 蛋白偶联受体，可刺激 cAMP 产生以响应血清素 (5-羟色胺) 。该基因产物是一种糖基化的跨膜蛋白，在外周和中枢神经系统中发挥作用，调节各种神经递质的释放。已经描述了编码具有不同 C 末端序列的蛋白质的多个转录变体。[RefSeq 提供，2010 年 5 月]

This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]

HTR4 基因产物(8)

mRNA Protein Name
NM_000870.7 NP_000861.1 5-hydroxytryptamine receptor 4 isoform b
NM_001040169.2 NP_001035259.1 5-hydroxytryptamine receptor 4 isoform a
NM_001040173.2 NP_001035263.1 5-hydroxytryptamine receptor 4 isoform i
NM_001040174.1
NM_001040172.2 NP_001035262.2 5-hydroxytryptamine receptor 4 isoform d
NR_104445.2
NM_001286410.1 NP_001273339.1 5-hydroxytryptamine receptor 4 isoform c
NM_199453.3 NP_955525.1 5-hydroxytryptamine receptor 4 isoform g
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled serotonin receptor activity IDA
IDA: 通过直接分析推断
9603189 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28298427 GOA
enables serotonin receptor activity IDA
IDA: 通过直接分析推断
33481771 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
9603189 GOA
involved in adenylate cyclase-activating serotonin receptor signaling pathway IDA
IDA: 通过直接分析推断
35714614 GOA
involved in large intestinal transit IDA
IDA: 通过直接分析推断
33481771 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15925089 GOA
located in membrane IDA
IDA: 通过直接分析推断
16102731 GOA
is active in plasma membrane IDA
IDA: 通过直接分析推断
10821780 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HTR4 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (36 - 312)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
蛋白主名 其他名称

5-hydroxytryptamine receptor 4

5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled

cardiac 5-HT4 receptor

关联疾病

疾病名称 别名
Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes
Irritable Bowel Syndrome

Irritable Colon

Psychogenic Ibs

Ibs - [Irritable Bowel Syndrome]

Spastic Bowel Syndrome
Headache

Headache Disorder
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis
Gastrointestinal System Disease

Gastrointestinal Disease

Gastrointestinal Diseases

Alimentary System Disease

Digestive System Disorder

Gastroenteropathy

Gastrointestinal Disorder

Git Disease

Digestive System Diseases

Gastrointestinal Disorders

Digestive System Disease

Digestive System Disorders
Colonic Pseudo-Obstruction

Primary Chronic Pseudo-Obstruction Of Colon
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Functional Gastric Disease
Pylorospasm
Constipation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-14153 Tegaserod 99.89% 否
HY-14153A Tegaserod maleate 99.90% 否
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-14153S Tegaserod-d11 / 否
HY-RS06474 HTR4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS06475 Htr4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS06476 Htr4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris HTR4 VGNC VGNC:41831
Bos taurus HTR4 VGNC VGNC:30000
Mus musculus HTR4 MGD MGI:109246
Felis catus HTR4 VGNC VGNC:67675
Macaca mulatta HTR4 VGNC VGNC:73544
Rattus norvegicus HTR4 RGD RGD:2850
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