GPR149 - G protein-coupled receptor 149 Gene

中文名称：G 蛋白偶联受体 149

种属: Homo sapiens

同用名: R35; IEDA; PGR10

关于 GPR149

功能概要

该基因编码一个七跨膜 G 蛋白偶联受体 (GPCR) A 类家族成员。虽然被归类为 A 类 GPCR，但编码的蛋白质缺少 A 类受体第三跨膜螺旋中发现的高度保守的 Asp-Arg-Tyr (DRY) 基序的前两个带电氨基酸，这对于有效的 G 蛋白偶联很重要信号转导。敲除直系同源基因的小鼠可以存活并且卵泡正常成熟，但显示出增强的生育能力和排卵。所有 GPCR 都有一个共同的结构体系结构，由七个跨膜 α 螺旋组成，这些螺旋由三个细胞外环和三个细胞内环相互连接。 GPCR 信号转导的一般特征是激动剂诱导的受体构象变化，导致异源三聚体 G 蛋白的激活，该蛋白由结合鸟嘌呤核苷酸的 G-α 亚基和二聚体 G-β-γ 亚基组成。然后活化的 G 蛋白结合并激活许多下游效应蛋白，这些效应蛋白产生第二信使，介导广泛的细胞和生理过程。[RefSeq 提供，2017 年 7 月]

This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged Amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors which is important for efficient G protein-coupled signal transduction. Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]