2. Gene
  3. Spg7 - SPG7 matrix AAA peptidase subunit, paraplegin Gene

Spg7 - SPG7 matrix AAA peptidase subunit, paraplegin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 353231 | 基因类型: protein coding

关于 Spg7

功能概要

Predicted to enable ATP binding activity; peptidase activity; and zinc ion binding activity. Involved in mitochondrial outer membrane permeabilization involved in programmed cell death. Predicted to be located in mitochondrial inner membrane. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin). [provided by Alliance of Genome Resources, Apr 2022]

Spg7 基因产物(2)

mRNA Protein Name
NM_001399110.1 NP_001386039.1 paraplegin isoform 2
NM_181388.3 NP_852053.1 paraplegin isoform 1
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitochondrial outer membrane permeabilization involved in programmed cell death IMP
IMP: 通过突变表型推断
26387735 RGD
involved in regulation of mitochondrial membrane permeability IMP
IMP: 通过突变表型推断
26387735 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

paraplegin

SPG7, paraplegin matrix AAA peptidase subunit

spastic paraplegia 7 homolog

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13663 SPG7 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21436 Spg7 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27954 Spg7 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Spg7 NCBI NCBI:6687
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