2. Gene
  3. TICAM2 - TIR domain containing adaptor molecule 2 Gene

TICAM2 - TIR domain containing adaptor molecule 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含 TIR 结构域的衔接分子 2

种属: Homo sapiens

同用名: TIRP; TRAM; TIRAP3; MyD88-4; TICAM-2

基因 ID: 353376 | 基因类型: protein coding

关于 TICAM2

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:115,578,496-115,602,479 (from NCBI)

This gene has 2 transcripts (splice variants) and 110 orthologues. Ubiquitous expression in appendix (RPKM 4.0), spleen (RPKM 3.2) and 25 other tissues.

功能概要

TIRP 是一种 Toll/interleukin-1 受体 (IL1R; MIM 147810) (TIR) 结构域，参与 Toll 受体信号转导 (参见 TLR4; MIM 603030) 。[OMIM 提供，2004 年 4 月]

TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]

TICAM2 基因产物(1)

mRNA Protein Name
NM_021649.7 NP_067681.1 TIR domain-containing adapter molecule 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular adaptor activity IDA
IDA: 通过直接分析推断
28630139 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17258210 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in TRAM-dependent toll-like receptor 4 signaling pathway IDA
IDA: 通过直接分析推断
19412184 GOA
involved in TRAM-dependent toll-like receptor 4 signaling pathway IMP
IMP: 通过突变表型推断
22685567 GOA
involved in cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
19412184 GOA
involved in cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
22685567 GOA
involved in negative regulation of chemokine (C-C motif) ligand 5 production IMP
IMP: 通过突变表型推断
19412184 GOA
involved in negative regulation of toll-like receptor 4 signaling pathway IDA
IDA: 通过直接分析推断
19412184 GOA
involved in phagocytosis IMP
IMP: 通过突变表型推断
30883606 GOA
involved in positive regulation of chemokine (C-C motif) ligand 5 production IMP
IMP: 通过突变表型推断
19412184 GOA
involved in positive regulation of interleukin-18-mediated signaling pathway IMP
IMP: 通过突变表型推断
22685567 GOA
involved in positive regulation of toll-like receptor 4 signaling pathway IDA
IDA: 通过直接分析推断
19412184 GOA
involved in positive regulation of toll-like receptor 4 signaling pathway IMP
IMP: 通过突变表型推断
22685567 GOA
involved in positive regulation of type I interferon production IDA
IDA: 通过直接分析推断
25385819 GOA
involved in toll-like receptor 4 signaling pathway IDA
IDA: 通过直接分析推断
28630139 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome IDA
IDA: 通过直接分析推断
19412184 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
19412184 GOA
is active in endosome IDA
IDA: 通过直接分析推断
28630139 GOA
is active in endosome membrane IDA
IDA: 通过直接分析推断
28630139 GOA
located in late endosome IDA
IDA: 通过直接分析推断
19412184 GOA
located in phagocytic cup IDA
IDA: 通过直接分析推断
30883606 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19412184 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TICAM2 蛋白结构

TIR_2

TIR_2: TIR domain (82 - 182)

  • 0
  • 100
  • 200
  • 235 a.a.
蛋白主名 其他名称

TIR domain-containing adapter molecule 2

NF-kappa-B-activating protein 502

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14518 TICAM2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TICAM2 MGD MGI:3040056
Rattus norvegicus TICAM2 RGD RGD:1308258
Bos taurus TICAM2 VGNC VGNC:55148
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