LILRA5 - leukocyte immunoglobulin like receptor A5 Gene

中文名称：白细胞免疫球蛋白样受体 A5

种属: Homo sapiens

同用名: CD85; LIR9; CD85F; ILT11; LIR-9; ILT-11; LILRB7

关于 LILRA5

功能概要

该基因编码的蛋白质是白细胞免疫球蛋白样受体 (LIR) 家族的成员。已知 LIR 家族成员在白细胞中具有激活和抑制功能。这种受体蛋白在单核细胞表面的交联已被证明可诱导钙流和多种促炎细胞因子的分泌，这表明该蛋白在触发先天免疫反应中的作用。该基因是在染色体区域 19q13.4 上形成基因簇的白细胞受体基因之一。已经描述了编码不同亚型的四种可变剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]