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  2. Nlrp1a - NLR family, pyrin domain containing 1A Gene

Nlrp1a - NLR family, pyrin domain containing 1A Gene

中文名称:NLR 家族,含 pyrin 结构域 1A

种属: Rattus norvegicus

同用名: Nalp1; Nlrp1

基因 ID: 360557 | 基因类型: protein coding

关于 Nlrp1a

Primary_assembly 10: 55,778,560-55,825,180 reverse strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 87 orthologues, 21 paralogues and is associated with 5 phenotypes. Biased expression in Thymus (RPKM 161.4), Spleen (RPKM 147.) and 8 other tissues.

功能概要

该基因编码的蛋白可启动支架蛋白结合活性。参与细胞防御反应的负调节和细胞焦亡的正调节。位于神经细胞体中。部分含蛋白质复合物。该基因的人类直系同源物与白斑有关。与人类 NLRP1 同源(NLR 家族 pyrin 结构域包含 1)。 [由基因组资源联盟提供,2022 年 4 月]

Enables scaffold protein binding activity. Involved in negative regulation of cellular defense response and positive regulation of Pyroptosis. Located in neuronal cell body. Part of protein-containing complex. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Nlrp1a 基因产物(1)

mRNA Protein Name
NM_001145755.2 NP_001139227.2 NACHT, LRR and PYD domains-containing protein 1a allele 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19416975 RGD
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
19416975 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cellular defense response IMP
IMP: 通过突变表型推断
24626226 RGD
involved in positive regulation of pyroptotic inflammatory response IMP
IMP: 通过突变表型推断
24626226 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in neuronal cell body IDA
IDA: 通过直接分析推断
19401709 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
19416975 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Nlrp1a 蛋白结构

NACHT

NACHT: pfam05729 (174 - 343)

NOD2_WH

NOD2_WH: cl39286 (413 - 467)

NLRC4_HD2

NLRC4_HD2: pfam17776 (469 - 580)

PPP1R42

PPP1R42: cl42388 (663 - 784)

LRR_RI

LRR_RI: sd00033 (673 - 694)

LRR_RI

LRR_RI: sd00033 (702 - 729)

LRR_RI

LRR_RI: sd00033 (730 - 758)

LRR_RI

LRR_RI: sd00033 (759 - 779)

FIIND

FIIND: pfam13553 (855 - 1107)

CARD_ASC_NALP1

CARD_ASC_NALP1: cd08330 (1127 - 1207)

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  • 1218 a.a.
蛋白主名 其他名称

NACHT, LRR and PYD domains-containing protein 1a allele 1

NACHT, LRR and PYD domains-containing protein 1

NACHT, LRR and PYD domains-containing protein 1a

NACHT, leucine rich repeat and PYD containing 1

NLR family protein 1

NLR family, pyrin domain containing 1

resistant anthrax lethal toxin