Kif14 - kinesin family member 14 Gene

中文名称：驱动蛋白家族成员 14

种属: Rattus norvegicus

关于 Kif14

功能概要

预计该基因编码的蛋白可启动多种功能，包括 ATP 绑定活动； ATP水解活性；和 PDZ 域绑定活动。预计参与多个过程，包括SCF依赖的蛋白酶体泛素依赖的蛋白质分解代谢过程；大脑发育；和细胞周期过程的调节。预计在几个过程的上游或内部起作用，包括整合素激活的负调节；调节 Rap 蛋白信号转导；和底物粘附依赖性细胞扩散。预测位于弗莱明体内；胞质溶胶；和主轴中间区。预计是驱动蛋白复合物的一部分。预计在微管中活跃。预测与质膜共定位。该基因的人类直系同源物与梅克尔综合征和原发性常染色体隐性小头畸形有关。与人类 KIF14（驱动蛋白家族成员 14）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and PDZ domain binding activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; brain development; and regulation of cell cycle process. Predicted to act upstream of or within several processes, including negative regulation of Integrin activation; regulation of Rap protein signal transduction; and substrate adhesion-dependent cell spreading. Predicted to be located in Flemming body; cytosol; and spindle midzone. Predicted to be part of Kinesin complex. Predicted to be active in microtubule. Predicted to colocalize with plasma membrane. Human ortholog(s) of this gene implicated in Meckel syndrome and primary autosomal recessive microcephaly. Orthologous to human KIF14 (Kinesin family member 14). [provided by Alliance of Genome Resources, Apr 2022]