2. Gene
  3. Ank3 - ankyrin 3 Gene

Ank3 - ankyrin 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: ANK-3

基因 ID: 361833 | 基因类型: protein coding

关于 Ank3

功能概要

Enables several functions, including Cadherin binding activity; spectrin binding activity; and transmembrane transporter binding activity. Involved in several processes, including clustering of voltage-gated sodium channels; positive regulation of protein targeting to membrane; and regulation of ion transport. Located in several cellular components, including Z disc; main axon; and spectrin-associated Cytoskeleton. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ANK3 (ankyrin 3). [provided by Alliance of Genome Resources, Apr 2022]

Ank3 基因产物(2)

mRNA Protein Name
NM_001033984.1 NP_001029156.1 ankyrin-3 isoform 2
NM_031805.2 NP_113993.1 ankyrin-3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cadherin binding IPI
IPI: 通过物理相互作用推断
17620337 RGD
enables cytoskeletal protein binding IPI
IPI: 通过物理相互作用推断
21223964 RGD
enables phosphorylation-dependent protein binding IPI
IPI: 通过物理相互作用推断
25950943 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12805291 RGD
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
17620337 RGD
enables spectrin binding IDA
IDA: 通过直接分析推断
17620337 RGD
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
15579534 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in anterograde axonal transport IMP
IMP: 通过突变表型推断
31474508 RGD
involved in axon development IMP
IMP: 通过突变表型推断
27098687 RGD
involved in clustering of voltage-gated sodium channels IMP
IMP: 通过突变表型推断
17709431 RGD
involved in establishment or maintenance of microtubule cytoskeleton polarity IMP
IMP: 通过突变表型推断
27098687 RGD
involved in maintenance of protein location in cell IMP
IMP: 通过突变表型推断
27098687 RGD
involved in membrane assembly IGI
IGI: 通过遗传相互作用推断
14757759 RGD
involved in negative regulation of endocytosis IMP
IMP: 通过突变表型推断
31474508 RGD
involved in neuromuscular junction development IEP
IEP: 通过表达模式推断
12657669 RGD
involved in positive regulation of cation channel activity IMP
IMP: 通过突变表型推断
18180363 RGD
involved in positive regulation of cell communication by electrical coupling IMP
IMP: 通过突变表型推断
21617128 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
18180363 RGD
involved in positive regulation of homotypic cell-cell adhesion IMP
IMP: 通过突变表型推断
21617128 RGD
involved in positive regulation of membrane depolarization during cardiac muscle cell action potential IMP
IMP: 通过突变表型推断
18180363 RGD
involved in positive regulation of membrane potential IMP
IMP: 通过突变表型推断
18180363 RGD
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
29079505 RGD
involved in positive regulation of protein targeting to membrane IMP
IMP: 通过突变表型推断
18180363 RGD
involved in positive regulation of sodium ion import across plasma membrane IMP
IMP: 通过突变表型推断
21617128 RGD
involved in positive regulation of sodium ion transmembrane transporter activity IMP
IMP: 通过突变表型推断
18180363 RGD
involved in positive regulation of sodium ion transport IMP
IMP: 通过突变表型推断
18180363 RGD
involved in protein localization to axon IMP
IMP: 通过突变表型推断
25950943 RGD
involved in protein localization to plasma membrane IGI
IGI: 通过遗传相互作用推断
14757759 RGD
involved in protein localization to plasma membrane IMP
IMP: 通过突变表型推断
18180363 RGD
involved in regulation of modification of postsynaptic structure IDA
IDA: 通过直接分析推断
25374361 RGD
involved in regulation of modification of postsynaptic structure IMP
IMP: 通过突变表型推断
25374361 RGD
involved in regulation of potassium ion transport IDA
IDA: 通过直接分析推断
16525039 RGD
involved in regulation of protein targeting IMP
IMP: 通过突变表型推断
18094255 RGD
involved in response to immobilization stress IEP
IEP: 通过表达模式推断
27824361 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in T-tubule IDA
IDA: 通过直接分析推断
15579534 RGD
located in Z disc IDA
IDA: 通过直接分析推断
9664041 RGD
located in axon IDA
IDA: 通过直接分析推断
17709431 RGD
located in axon initial segment IDA
IDA: 通过直接分析推断
11724816 RGD
located in axon initial segment IMP
IMP: 通过突变表型推断
25950943 RGD
located in cell surface IDA
IDA: 通过直接分析推断
21223964 RGD
located in costamere IDA
IDA: 通过直接分析推断
11171381 RGD
located in dendrite IDA
IDA: 通过直接分析推断
18786578 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
25374361 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
25374361 RGD
located in intercalated disc IDA
IDA: 通过直接分析推断
15579534 RGD
located in neuromuscular junction IDA
IDA: 通过直接分析推断
12657669 RGD
located in node of Ranvier IDA
IDA: 通过直接分析推断
17548513 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
16525039 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
25374361 RGD
is active in postsynapse IMP
IMP: 通过突变表型推断
25374361 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
9664041 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
11796721 RGD
located in sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
9664041 RGD
located in spectrin-associated cytoskeleton IDA
IDA: 通过直接分析推断
17620337 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ankyrin-3

ankyrin 3 (G)

ankyrin 3, epithelial

ankyrin 3, node of Ranvier (ankyrin G)

ankyrin-G

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00701 ANK3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19574 Ank3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26071 Ank3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ank3 NCBI NCBI:288
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