2. Gene
  3. Map3k5 - mitogen-activated protein kinase kinase kinase 5 Gene

Map3k5 - mitogen-activated protein kinase kinase kinase 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶激酶激酶 5

种属: Rattus norvegicus

同用名: Ask1; RGD1306565

基因 ID: 365057 | 基因类型: protein coding

关于 Map3k5

Primary_assembly 1: 14,685,492-14,904,800 forward strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 29 phenotypes. Biased expression in Adrenal (RPKM 13.), Kidney (RPKM 13.) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 MAP 激酶激酶激酶活性。参与多个过程，包括内皮细胞凋亡过程； MAPK 级联的正调控；心肌细胞凋亡过程的正调控作用。位于胞质溶胶和质膜外侧。用于研究脑梗塞和心肌梗塞。膜性肾小球肾炎的生物标志物；短暂性脑缺血；和视觉性癫痫。该基因的人类直系同源物与亨廷顿病有关。与人 MAP3K5（丝裂原活化蛋白激酶激酶激酶 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables MAP kinase kinase kinase activity. Involved in several processes, including endothelial cell apoptotic process; positive regulation of MAPK cascade; and positive regulation of cardiac muscle cell apoptotic process. Located in cytosol and external side of plasma membrane. Used to study cerebral infarction and myocardial infarction. Biomarker of membranous glomerulonephritis; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Map3k5 基因产物(1)

mRNA Protein Name
NM_001277694.1 NP_001264623.1 mitogen-activated protein kinase kinase kinase 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MAP kinase kinase kinase activity IDA
IDA: 通过直接分析推断
20550965 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12050113 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in JNK cascade IDA
IDA: 通过直接分析推断
12524169 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: 通过表达模式推断
16157298 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
20716917 RGD
involved in endothelial cell apoptotic process IEP
IEP: 通过表达模式推断
17932313 RGD
involved in positive regulation of JUN kinase activity IMP
IMP: 通过突变表型推断
20716917 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
22635076 RGD
involved in positive regulation of p38MAPK cascade IMP
IMP: 通过突变表型推断
20716917 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
20550965 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
14638553 RGD
involved in response to endoplasmic reticulum stress IEP
IEP: 通过表达模式推断
12050113 RGD
involved in response to ischemia IEP
IEP: 通过表达模式推断
20550965 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
12786973 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Map3k5 蛋白结构

DUF4071

DUF4071: pfam13281 (171 - 551)

ASK_PH

ASK_PH: pfam19039 (561 - 660)

STKc_ASK

STKc_ASK: cd06624 (677 - 944)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1381 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase 5

apoptosis signal regulating kinase 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08058 MAP3K5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS08059 Map3k5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS08060 Map3k5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Map3k5 NCBI NCBI:4217
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z