2. Gene
  3. USP50 - ubiquitin specific peptidase 50 Gene

USP50 - ubiquitin specific peptidase 50 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素特异性肽酶 50

种属: Homo sapiens

基因 ID: 373509 | 基因类型: protein coding

关于 USP50

This gene has 11 transcripts (splice variants), 172 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 3.5), bone marrow (RPKM 2.9) and 25 other tissues.

功能概要

启用泛素样蛋白特异性蛋白酶活性。作用于多个过程的上游或内部，包括核斑点组织； NLRP3 炎性体复合物组装的正向调控；和大分子代谢过程的正向调控。预计在几种细胞成分中具有活性，包括树突棘；中体;和突触后密度。预测为核内体膜的外在成分和质膜的外在成分。 [由基因组资源联盟提供，2022 年 4 月]

Enables ubiquitin-like protein-specific protease activity. Acts upstream of or within several processes, including nuclear speck organization; positive regulation of NLRP3 inflammasome complex assembly; and positive regulation of macromolecule metabolic process. Predicted to be active in several cellular components, including dendritic spine; midbody; and postsynaptic density. Predicted to be extrinsic component of endosome membrane and extrinsic component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

USP50 基因产物(1)

mRNA Protein Name
NM_203494.5 NP_987090.2 inactive ubiquitin carboxyl-terminal hydrolase 50
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
28094437 GOA
enables ubiquitin-like protein peptidase activity IDA
IDA: 通过直接分析推断
28094437 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within nuclear speck organization IMP
IMP: 通过突变表型推断
28094437 GOA
acts upstream of or within positive regulation of NLRP3 inflammasome complex assembly IMP
IMP: 通过突变表型推断
28094437 GOA
acts upstream of or within positive regulation of cysteine-type endopeptidase activity IMP
IMP: 通过突变表型推断
28094437 GOA
acts upstream of or within positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
28094437 GOA
acts upstream of or within protein deubiquitination IDA
IDA: 通过直接分析推断
28094437 GOA
involved in regulation of cell cycle G2/M phase transition IMP
IMP: 通过突变表型推断
20930503 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
20930503 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
20930503 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20930503 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

USP50 蛋白结构

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (43 - 330)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
蛋白主名 其他名称

inactive ubiquitin carboxyl-terminal hydrolase 50

inactive ubiquitin-specific peptidase 50

关联疾病

疾病名称 别名
Spondyloarthropathy 1

Ankylosing Spondylitis

Spondyloarthropathy, Susceptibility To, 1

SPDA1

Marie-Strumpell Spondylitis

Bechterew Syndrome

Spa

Spondylarthritis Ankylopoietica

Reiter Syndrome

Ankylosing Spondylitis, Susceptibility To

Bekhterev Syndrome

Bekhterev'S Disease

Marie-Strumpell Disease

Axial Spondylarthritis

Bechterew Disease

Marie-Struempell Disease

Spondylitis Ankylopoietica

Spondyloarthritis

Spondyloarthritis Ankylopoietica

Spas

Ankylosing Spondylarthritis

Psoriatic Arthritis

Reactive Arthritis

Rheumatoid Spondylitis

Spondylitis Ankylosans

Spondylitis Ankylosing

Spondylitis, Ankylosing

Spondylarthropathies

Arthritis, Psoriatic

Arthritis, Reactive
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15562 USP50 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22904 Usp50 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29418 Usp50 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris USP50 VGNC VGNC:55016
Rattus norvegicus USP50 RGD RGD:1564751
Bos taurus USP50 VGNC VGNC:52848
Felis catus USP50 VGNC VGNC:66894
Mus musculus USP50 MGD MGI:1922333
Macaca mulatta USP50 VGNC VGNC:79232
Others USP50 NCBI
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